1
John P Wikswo, Franz J Baudenbacher, Owen McGuinness: Device and methods for monitoring the status of at least one cell. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, October 14, 2008: US07435578 (12 worldwide citation)

A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opp ...


2
Franz Baudenbacher, John P Wikswo, R Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich: Apparatus and methods for monitoring the status of a metabolically active cell. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, April 27, 2010: US07704745 (5 worldwide citation)

An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the stat ...


3
John P Wikswo, Franz J Baudenbacher, Owen McGuinness: Device and methods for monitoring the status of at least one cell. Vanderbilt University, Morris Manning & Martin, July 14, 2005: US20050153273-A1

A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opp ...


4
John P Wikswo, Theodore Bapty, Franz J Baudenbacher, Owen McGuinness, Ales Prokop, R Robert Balcarcel: System and methods for discriminating an agent. Vanderbilt University, Merchant & Gould PC, July 14, 2005: US20050153276-A1

A system and methods for discriminating an agent. In one embodiment of the present invention, the method includes the steps of (a) constructing a decision tree having a plurality of branches, each branch corresponding to at least one defined action, wherein each branch includes a plurality of succes ...


5
John P Wikswo, David Osterman, Franz J Baudenbacher, Owen McGuinness, Ales Prokop: Device and methods for measuring the response of a least one cell to a medium. Morris Manning & Martin, July 21, 2005: US20050158845-A1

An apparatus and methods for measuring response of at least one cell to a medium, the response of at least one cell to a medium being characterized by a reaction time. In one embodiment of the present invention, the device includes a membrane and a side substrate defining a sample well in communicat ...


6
John P Wikswo, Franz J Baudenbacher, R Robert Balcarcel, Theodore A Bapty, David Cliffel, Sven Eklund, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich, Yang Yuansheng: Apparatus and methods for using biological material to discriminate an agent. Tim Tingkang Xia, Morris Manning & Martin, April 6, 2006: US20060073539-A1

An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical qu ...


7
Franz J Baudenbacher, John P Wikswo, R Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich: Apparatus and methods for monitoring the status of a metabolically active cell. Morris Manning Martin, December 10, 2009: US20090305319-A1

An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the stat ...


8
John P Wikswo, Franz J Baudenbacher, R Robert Balcarcel, Theodore A Bapty, David Cliffel, Sven Eklund, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich, Yang Yuansheng: Apparatus and Methods for Using Biological Material to Discriminate an Agent. Vanderbilt University, June 21, 2012: US20120156763-A1

An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical qu ...