1
Holy Antonin, Otmar Miroslav, Piskala Alois: Method of manufacturing 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, GABRIELOVA Marta, August 28, 2008: WO/2008/101448 (2 worldwide citation)

This invention relates to a method of manufacturing 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine by the treatment of protected alkyl or aralkyl 2-deoxy-D-erythro-pentofuranoside with silylated 5-azacytosine in the presence of Lewis acid and subsequent removal the protecting groups.


2
Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva: 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine for use as drug. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva, GABRIELOVA Marta, July 17, 2008: WO/2008/083634

The invention relates to 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine of formula (I) for use as a hypomethylating drug applicable for epigenetic therapy of cancer and other epigenetically determined diseases and further includes the use of the compound of formula (I) for manufacturing of ...