1
Omar S Khalil, Shu jen Yeh, Charles F Hanna, Stanislaw Kantor: Method for the non-invasive determination of analytes in a selected volume of tissue. Abbott Laboratories, David L Weinstein, February 25, 2003: US06526298 (329 worldwide citation)

A method for the determination of concentrations of analytes, e.g., glucose, and other metabolites in human tissue, wherein the temperature of a defined cutaneous volume of tissue, e.g., human skin, is controlled. The method involves calculating the concentration of an analyte in the tissue by takin ...


2
Omar S Khalil, Shu Jen Yeh, Xiaomao Wu, Stanislaw Kantor, Charles F Hanna, Tzyy Wen Jeng: Method for modulating light penetration depth in tissue and diagnostic applications using same. Abbott Laboratories, David L Weinstein, May 9, 2006: US07043287 (228 worldwide citation)

Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte, in a biological sample, such as, for example, a body part. In these devices and me ...


3
Tzyy Wen Jeng, Shu Jen Yeh, John M Lindberg, Joseph Larry Pezzaniti, Omar S Khalil, Gary M Oosta, Charles F Hanna, Arnold F Stalder, Ete Z Szuts: Method and apparatus for non-invasively measuring the amount of glucose in blood. Abbott Laboratories, David L Weinstein, May 23, 2000: US06067463 (218 worldwide citation)

A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively, i.e., without penetrating the skin or obtaining a biological sample from the body of a patient. The method and apparatus uses a plurality of measurement channels with appropriate ...


4
Omar S Khalil, Shu jen Yeh, Stanislaw Kantor, Charles F Hanna, Eric B Shain: Method for optical measurements of tissue to determine disease state or concentration of an analyte. Abbott Laboratories, David L Weinstein, January 23, 2007: US07167734 (142 worldwide citation)

A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserte ...


5
Stanley R Bouma, Omar S Khalil, Edward K Pabich: Method for detection of nucleic acid using total internal reflectance. Abbott Laboratories, Thomas D Brainard, Paul D Yasger, December 17, 1996: US05585242 (136 worldwide citation)

An apparatus and method for detecting amplified target nucleic acid is provided wherein the presence and concentration of amplified target is determined by total internal reflection over the course of the amplification reaction. A method and apparatus for detecting target nucleic acid is also provid ...


6
Omar S Khalil, Xiaomao Wu, Shu jen Yeh, Charles F Hanna, Stanislaw Kantor, Tzyy Wen Jeng: Optical sensor having a selectable sampling distance for determination of analytes. Abbott Laboratories, David L Weinstein, September 2, 2003: US06615061 (121 worldwide citation)

A method and apparatus for the measurement of trans-cutaneous diffuse reflectance at a single sampling distance for determining the concentration of an analyte in a biological sample, such as, for example, human tissue. The determination of the concentration of the analyte has been found to depend o ...


7
Omar S Khalil, Charles F Hanna, Thomas F Zurek, Denise A Grigalauski: Immunoassay device with liquid transfer between wells by washing. Abbott Laboratories, Priscilla E Porembski, April 9, 1991: US05006309 (114 worldwide citation)

A disposable device suitable for performing automated solid-state diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by a ...


8
Omar S Khalil, Frits F M de Mul, Charles F Hanna, Arnold F Stalder, Shu jen Yeh, Xiaomao Wu, Michael G Lowery, Johannes S Kanger, René A Bolt: Non-invasive sensor having controllable temperature feature. Abbott Laboratories, David L Weinstein, December 9, 2003: US06662030 (111 worldwide citation)

Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence or concentration of an analyte, in a body part wherein the temperature is controlled. The present invention measures light that is reflected, scattered, absorbed, or emitted by the sample from a ...


9
Omar S Khalil, Thomas F Zurek, Kevin R Genger, Curtis J Pepe, Yi Her Jou, Stephen M Cotter: Method and apparatus for heterogeneous chemiluminescence assay. Abbott Laboratories, Priscilla E Porembski, Daniel W Collins, February 18, 1992: US05089424 (105 worldwide citation)

Apparatus and method for performing a chemiluminescence assay involving the immobilization of a chemiluminescent reaction complex to a solid, porous element. The solid, porous element is preferably treated to provide an immobilizing interaction with the chemiluminescent reaction complex wherein the ...


10
Omar S Khalil, Xiaomao Wu, Johannes Sake Kanger, Rene′ Alexander Bolt, Shu Jen Yeh, Charles F Hanna, Frits Frans Maria de Mul: Non-invasive sensor capable of determining optical parameters in a sample having multiple layers. Abbott Laboratories, David L Weinstein, March 5, 2002: US06353226 (76 worldwide citation)

Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The ...