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Oleksyszyn Jozef, Kirschenheuter Gary P: Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase.. Cortech, October 12, 1994: EP0618899-A1

Compounds of the formula (I) (II) or (III) wherein: R1, R2, R3 and R4, which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups -(CH2)n-where n is a whole ...


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Oleksyszyn Jozef, Kirschenheuter Gary Paul: Esters aromatiques de phenylenedialcanoates utilises comme inhibiteurs de lelastase de neutrophiles humains, Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase. Cortech, Cortech, OSLER HOSKIN & HARCOURT, June 24, 1993: CA2126195

Compounds of the formulae (I, II or III) wherein: R1, R2, R3 and R4 which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups -(CH2)n- where n is a whole n ...


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Powers James C, Boduszek Bogdan, Oleksyszyn Jozef: Proline phosphonate derivatives. Georgia Tech Research Corporation, COLTON Laurence P, November 9, 1995: WO/1995/029691

Peptidyl derivatives of diesters of $g(a)-aminoalkylphosphonic acids, particularly those with proline or related structures, their use in inhibiting serine proteases with chymotrypsin-like, trypsin-like, elastase-like, and dipeptidyl peptidase IV specificity and their roles as anti-inflammatory agen ...


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Oleksyszyn Jozef, Kirschenheuter Gary P: Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase. Cortech, NESBITT Stephen L, June 24, 1993: WO/1993/011760

Compounds of the formulae (I, II or III) wherein: R¿1?, R¿2?, R¿3? and R¿4? which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups -(CH¿2?)¿n?- where n ...


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Oleksyszyn Jozef, Jacobson Alan R: Substituted 5-amino-1,3,4-thiadiazole-2-thiones. Proscript, Oleksyszyn Jozef, Jacobson Alan R, GOLDSTEIN Jorge A, June 18, 1998: WO/1998/025949

The use of N5-substituted 5-amino-1,3,4-thiadiazole-2-thiols as metalloproteinases to inhibit matrix metalloproteinase enzymes and cartilage degradation is disclosed. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, a ...


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