1
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


2
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, January 14, 2004: EP1380562-A1 (14 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


3
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


4

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Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Derive de lacide carboxylique et son sel, Carboxylic acid derivative and salt thereof. Eisai, Eisai R&D Management, Smart & Biggar, February 8, 2011: CA2442319

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides acarboxylic acid compound represented by the following formu ...


6
ASANO OSAMU, HARADA HITOSHI, YOSHIKAWA SEIJI, WATANABE NOBUHISA, INOUE TAKASHI, HORIZOE TATSUO, YASUDA NOBUYUKI, OHASHI KAYA, MINAMI HIROE, NAGAOKA JUNSAKU, MURAKAMI MANABU, KOBAYASHI SEIICHI, TANAKA ISAO, KAWATA TSUTOMU, SHIMOMURA NAOYUKI, AKAMATSU HIROSHI, OZEKI NAOKI, SHIMIZU TOSHIKAZU, HAYASHI KENJI, HAGA TOYOKAZU, NEGI SHIGETO, NAITO TOSHIHIKO: COMPOSES IMIDAZOLE FUSIONNES ET MEDICAMENTS CONTRE LE DIABETE SUCRE, CONDENSED IMIDAZOLE COMPOUNDS AND A THERAPEUTIC AGENT FOR DIABETES MELLITUS. EISAI, EISAI R&D MANAGEMENT, SMART & BIGGAR, September 15, 2009: CA2376835

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


7
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya, FURUYA Kaoru, December 19, 2002: WO/2002/100812

A medicine containing as the active ingredient a novel carboxylic acid derivative useful as an insulin resistance ameliorant. The carboxylic acid derivative is represented by the following general formula (I). Also provided are a salt or ester of the derivative and a hydrate of either. (I) In the fo ...


8
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai R&Amp Amp D Management, December 6, 2003: KR1020037013180

A medicine containing as the active ingredient a novel carboxylic acid derivative useful as an insulin resistance ameliorant. The carboxylic acid derivative is represented by the following general formula (I). Also provided are a salt or ester of the derivative and a hydrate of either. (I) In the fo ...


9
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu, Negi Shigeto, Naito Toshihiko: Fused imidazole compounds and remedies for diabetes mellitus. Eisai R&Amp Amp D Management, February 27, 2002: KR1020017016643

Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R1 is optionally alkyla ...