1
Nurith Kurn: Methods and compositions for linear isothermal amplification of polynucleotide sequences, using a RNA-DNA composite primer. Nugen Technologies, Morrison & Foerster, June 26, 2001: US06251639 (216 worldwide citation)

The present invention provides novel isothermal, single primer linear nucleic acid amplification methods. Methods for amplifying complementary DNA using a composite primer, primer extension, strand displacement, and optionally a termination sequence, are provided. Methods for amplifying sense RNA us ...


2
Geoffrey A Dafforn, Nurith Kurn, Martin Becker, Edwin F Ullman: Multiple port assay device. Syntex, Theodore J Leitereg, January 1, 1991: US04981786 (128 worldwide citation)

A device is disclosed for conducting an assay. The device comprises a housing, means enclosed in the housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from the zone, first means in the housing for introd ...


3
Nurith Kurn, Chander Bahl, Edwin F Ullman: Homogeneous assay for specific polynucleotides. Syntex, Theodore J Leitereg, September 19, 1989: US04868104 (91 worldwide citation)

A method for determining the presence of a polynucleotide analyte in a sample suspected of containing the analyte is disclosed. The method comprises combining in an assay medium the sample and first and second polynucleotide reagents complementary to the analyte. Each of the first and second reagent ...


4
Edwin F Ullman, Vartan E Ghazarossian, Nurith Kurn, Litai Weng: Particle separation method. Syntex, Theodore J Leitereg, June 19, 1990: US04935147 (78 worldwide citation)

A method is disclosed for separating a substance from a liquid medium. The method comprises combining the liquid medium containing the substance with magnetic particles under conditions for non-specific chemical binding of the magnetic particles. Thereafter, the medium is subjected to a magnetic fie ...


5
Yen Ping Liu, Rajesh D Patel, Nurith Kurn, Claire Lin, Samuel J Rose, Edwin F Ullman: Homogeneous amplification and detection of nucleic acids. Dade Behring, Theodore J Leitereg, June 22, 1999: US05914230 (72 worldwide citation)

The present invention relates to a method for detecting or amplifying and detecting a target polynucleotide sequence. The method comprises providing in combination (i) a medium suspected of containing the target polynucleotide sequence, (ii) all reagents required for conducting an amplification of t ...


6
Nurith Kurn: Methods and compositions for linear isothermal amplification of polynucleotide sequences. NuGEN Technologies, Morrison & Foerster, February 17, 2004: US06692918 (63 worldwide citation)

The present invention provides novel isothermal, single primer linear nucleic acid amplification methods. Methods for amplifying complementary DNA using a composite primer, primer extension, strand displacement, and optionally a termination sequence, are provided. Methods for amplifying sense RNA us ...


7
Nurith Kurn: Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers. NuGEN Technologies, Morrison & Foerster, September 20, 2005: US06946251 (56 worldwide citation)

The invention provides methods for isothermal amplification of RNA. The methods are particularly suitable for amplifying a plurality of RNA species in a sample. The methods employ a composite primer, a second primer and strand displacement to generate multiple copies of DNA products comprising seque ...


8
Nurith Kurn: Methods and probes for detection and/or quantification of nucleic acid sequences. NuGEN Technologies, Morrison & Foerster, November 9, 2004: US06815164 (52 worldwide citation)

The present invention discloses nucleic acid detector probes for specific detection and/or quantification of target nucleic acid sequences and detection and/or quantification methods using these probes. In the absence of target nucleic acid sequence, a first oligonucleotide and a third oligonucleoti ...


9
Edwin F Ullman, Vartan E Ghazarossian, Nurith Kurn, Litai Weng: Magnetic composition for particle separation. Syntex, Theodore J Leitereg, December 31, 1991: US05076950 (50 worldwide citation)

A method is disclosed for separating a substance from a liquid medium. The method comprises combining the liquid medium containing the substance with magnetic particles under conditions for non-specific chemical binding of the magnetic particles. Thereafter, the medium is subjected to a magnetic fie ...


10
Nurith Kurn: Methods and compositions for transcription-based nucleic acid amplification. NuGen Technologies, Morrison & Foerster, February 3, 2004: US06686156 (41 worldwide citation)

Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in RNA transcripts, and a second module providing for further (generally cyclical) amplification resultin ...