1
Norbert W Bischofberger, Mark D Matteucci: Nucleic acid intercalating agents. Genentech, Daryl B Winter, Max D Hensley, December 29, 1992: US05175273 (237 worldwide citation)

Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings are provided. These polycyclic nucleosides are incorporated into oligonucleotides and hybridized to complementary nucleic acid. Fluorescence spectroscopy and thermal denaturation profiles provided evidence that th ...


2
Chris Buhr, Mark Matteucci, Norbert W Bischofberger, Brian Froehler: Nucleoside 5-methylene phosphonates. Gilead Sciences, Daryl D Muenchau, September 30, 1997: US05672697 (146 worldwide citation)

Novel oligonucleotides analogs and nucleoside analogs as well as methods for their synthesis are described. The oligonucleotides are useful in diagnostic and therapeutic applications. The oligonucleotides are stable to nuclease degradation.


3
Norbert W Bischofberger, Robert J Jones, Murty N Arimilli, Kuei Ying Lin, Michael S Louie, Lawrence R McGee, Ernest J Prisbe, William A Lee, Kenneth C Cundy: Nucleotide analogs. Gilead Sciences, Max D Hensley, May 1, 2001: US06225460 (49 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding ph ...


4
Norbert W Bischofberger, Robert J Jones, Murty N Arimilli, Michael S Louie, Ernest J Prisbe, William A Lee: Nucleotide analogs. Gilead Sciences, Daryl D Muenchau, August 25, 1998: US05798340 (47 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate lirked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding ph ...


5
Norbert W Bischofberger, Kenneth M Kent: Method and cyclic carbonates for nucleotide analogues. Gilead Sciences, Max D Hensley, May 7, 1996: US05514798 (27 worldwide citation)

An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl n ...


6
Norbert W Bischofberger, Choung U Kim, Steven H Krawczyk, Lawrence R McGee, Michael J Postich, Wenjin Yang: Thiepane compounds. Gilead Sciences, Mark L Bosse, March 7, 2000: US06034118 (21 worldwide citation)

Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detectio ...


7
Norbert W Bischofberger: PMPA preparation. Gilead Sciences, Max D Hensley, March 31, 1998: US05733788 (20 worldwide citation)

Purified preparations of PMPA are provided, together with analytical methods for the detection of undesired contaminants in PMPA preparations. The PMPA compositions of the invention are of particular utility in therapeutics intended for the treatment or prophylaxis of viral infections.


8
Murty N Arimilli, Norbert W Bischofberger, Robert J Jones, William A Lee, Ernest J Prisbe: Nucleotide analogs. Gilead Sciences, Daryl D Muenchau, March 23, 1999: US05886179 (18 worldwide citation)

Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods a ...


9
Norbert W Bischofberger, Choung U Kim, Willard Lew, Hongtao Liu, Matthew A Williams: Carbocyclic compounds. Gilead Sciences, Mark L Bosse, June 9, 1998: US05763483 (17 worldwide citation)

Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of ...


10
Norbert W Bischofberger, Choung U Kim, Willard Lew, Hongtao Liu, Matthew A Williams: Compounds and methods for synthesis and therapy. Gilead Sciences, Mark L Bosse, September 14, 1999: US05952375 (15 worldwide citation)

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting ...