1
Masaaki Matsuo, Kiyoshi Tsuji, Nobukiyo Konishi, Katsuya Nakamura: Pyrazole derivatives, and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, July 28, 1992: US05134142 (104 worldwide citation)

The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.


2
Matsuo Masaaki, Hagiwara Daijiro, Manabe Takashi, Nobukiyo Konishi, Shigenaga Shinji, Murano Kenji, Matsuda Hiroshi, Miyake Hiroshi: Piperazine derivatives as tachykinin antagonists.. Fujisawa Pharmaceutical Co, May 31, 1995: EP0655442-A1 (56 worldwide citation)

A compound of the following general formula : wherein X is carbonyl or sulfonyl; Y is bond or lower alkylene; R is halogen, lower alkyl, halo(lower)alkyl, aryloxy, nitro or amino which may have 1 or 2 and same or different substituent(s) selected from lower alkyl, acyl and lower alkanesulfonyl; R is ...


3
Masaaki Matsuo, Kiyoshi Tsuji, Takashi Ogino, Nobukiyo Konishi: Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, August 27, 1996: US05550147 (18 worldwide citation)

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower al ...


4
Masaaki Matsuo, Kiyoshi Tsuji, Nobukiyo Konishi, Katsuya Nakamura: Thiophene derivatives. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, November 5, 1996: US05571810 (17 worldwide citation)

This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsu ...


5

6
Masaaki Matsuo, Kiyoshi Tsuji, Nobukiyo Konishi: Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, September 12, 1989: US04866091 (11 worldwide citation)

This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,


7
Ikuo Ueda, Yoshihiko Kitaura, Nobukiyo Konishi: Phenoxyphenyl acetic acids and their medicinal use. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, September 18, 1984: US04472433 (7 worldwide citation)

A compound of the formula: ##STR1## wherein R.sup.1 is phenyl substituted with halogen or lower alkyl, and R.sup.4 is a group of the formula C.sub.n H.sub.2n in which n is an integer of 1 to 7; or a pharmaceutically acceptable salt thereof. The compound exhibits antipyretic, analgesic and anti-infla ...


8

9
Ikuo Ueda, Yoshihiko Kitaura, Masaaki Matsuo, Nobukiyo Konishi: Phenyl-alkanoic acid derivative and preparation thereof. Fujisawa Pharmaceutical Company, Oblon Fisher Spivak McClelland & Maier, January 4, 1983: US04367238 (6 worldwide citation)

This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.


10
Masaaki Matsuo, Kiyoshi Tsuji, Takashi Ogino, Nobukiyo Konishi: Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, September 23, 1997: US05670533 (6 worldwide citation)

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower) alkyl, cyano, lower a ...