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Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki: Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a coelomycetes strain.. Fujisawa Pharmaceutical Co, December 27, 1991: EP0462531-A2 (36 worldwide citation)

A polypeptide compound of the following general formula : wherein R is hydrogen or acyl group, R is hydroxy or acyloxy, R is hydrogen or hydroxysulfonyloxy, and R is hydrogen or carbamoyl, with proviso that (i) R is acyloxy, when R is hydrogen, and (ii) R is not palmitoyl, when R is hydroxy, R is hy ...


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Masakuni Okuhara, Toshio Goto, Yasuhiro Hori, Takashi Fujita, Hirotsugu Ueda, Nobuharu Shigematsu: FR901228 substance and preparation thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, December 11, 1990: US04977138 (35 worldwide citation)

The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##


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Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara: Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, March 26, 1996: US05502033 (3 worldwide citation)

A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt ...


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Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu: Process for producing WS-9326A and WS-9326B. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, July 25, 1995: US05436140 (3 worldwide citation)

The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives ther ...


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Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu: Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, June 8, 1993: US05217952 (1 worldwide citation)

This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.


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Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase: WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, December 1, 1992: US05167958 (1 worldwide citation)

A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.


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Takahisa Furuta, Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara: Use of the polypeptide compound. March 4, 1997: USH0001638

A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hyd ...