1
Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A Virsik: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use. XenoPort, Polsinelli PC, July 15, 2014: US08778991 (43 worldwide citation)

Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel ...


2
Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A Gallop: Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, April 1, 2008: US07351740 (18 worldwide citation)

Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl) -cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl) -cyclohexanecarboxylic acid and pharmaceu ...


3
Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A Virsik: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use. XenoPort, Dorsey & Whitney, April 3, 2012: US08148414 (17 worldwide citation)

Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel ...


4
Noa Zerangue: LAT1 transporters expressed in blood brain barrier cells. XenoPort, Townsend and Towsend and Crew, December 9, 2008: US07462459 (9 worldwide citation)

LAT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the LAT1 transporter, and therefore a candidate substrate for crossing the blood b ...


5
Mark Gallop, Kenneth C Cundy, Randall A Scheuerman, Ronald W Barrett, Noa Zerangue: Amino acid conjugates providing for sustained systemic concentrations of GABA analogues. Xenoport, Buchanan Ingersoll & Rooney P C, September 2, 2008: US07420002 (5 worldwide citation)

Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.


6
Bernd Jandeleit, Yunxiao Li, Mark A Gallop, Noa Zerangue, Peter A Virsik, Wolf Nicolas Fischer: Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use. XenoPort, Dorsey & Whitney, May 1, 2012: US08168617 (4 worldwide citation)

Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and ...


7
Noa Zerangue, Qingzhi Gao, William J Dower: Creatine phosphate analog prodrugs, compositions and uses thereof. XenoPort, Kilpatrick Townsend & Stockton, June 19, 2012: US08202852 (3 worldwide citation)

Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine ...


8
Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A Gallop: Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, August 17, 2010: US07777070 (1 worldwide citation)

Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceuti ...


9
Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A Gallop: Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, September 22, 2009: US07592369 (1 worldwide citation)

Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceuti ...


10
Noa Zerangue, Tracy Dias, William J Dower: Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter. Xenoport, Townsend and Townsend and Crew, March 24, 2009: US07507546 (1 worldwide citation)

The invention provides methods of screening agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the PEPT2 transporter. The invention also provides methods of treatment involving delivery of agents that either alone, or as a res ...