1
Yabe Yuichiro, Sakurai Mitsuya, Higashida Susumu, Komai Tomoaki, Nishigaki Takashi, Handa Hiroshi: New beta-amino-alpha-hydroxycarboxylic acids and their use.. Sankyo, August 12, 1992: EP0498680-A1 (58 worldwide citation)

The compounds of the invention are beta -amino- alpha -hydroxycarboxylic acid derivatives having the formula (I): wherein: R represents a group of formula R(Z)xA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula - ...


2
Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi, Kimura Tomio, Katsube Tetsushi: Remedies or preventives for aids. Sankyo, Ube Industries, November 18, 1998: EP0878194-A1 (7 worldwide citation)

The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing ...


3
Takahashi Yasunobu, Seko Maomi, Ide Akira, Matumoto Soziro, Nishigaki Takashi: Process for producing aliphatic polyisocyanates. Asahi Kasei Kogyo Kabushiki Kaisha, Flynn & Frishauf, July 22, 1975: US3896154 (6 worldwide citation)

An aliphatic polyisocyanate is prepared by adding water to a mixture containing an aromatic hydrocarbon or a nucleus substituted derivative thereof and hexamethylene diisocyanate, which is preliminarily heated at a temperature in the range from 100.degree. to 140.degree.C, under agitation in an amou ...


4
Miyake Koji, Hatsuda Takumi, Fujita Sachio, Nishigaki Takashi, Ishizaki Kunihiko, Kajikawa Katsuhiro: Continuous manufacturing method of water-absorbent polymer. Nippon Catalytic Chem, May 9, 2001: EP1097946-A2 (2 worldwide citation)

A continuous manufacturing method of a water-absorbent polymer by continuously performing a polymerization of a hydrophilic monomer using a solution containing a hydrophilic monomer, includes at least one of the following, steps (A) to (D): (A) introducing an inert gas into the solution in a continu ...


5
Nishigaki Takashi, Hatsuda Takumi, Miyake Koji, Ishizaki Kunihiko: Method for conveying hydrous gel. Nippon Shokubai, May 15, 2001: JP2001-131218 (2 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for conveying a hydrous gel whereby the gel is prevented from sticking to the carrying surface of a conveying means and can be smoothly conveyed. SOLUTION: When a hydrous gel 19 obtained by polymerizing a water-soluble ethylenic unsaturated monomer is convey ...


6
Koizumi Makoto, Kaneko Masakatsu, Omine Hisanori, Furukawa Hidehiko, Nishigaki Takashi: Anti-aids agent containing modified oligodeoxyribonucleotide having tggg sequence. Sankyo, October 17, 2000: JP2000-290185 (2 worldwide citation)

PROBLEM TO BE SOLVED: To obtain the subject agent exhibiting remarkably high anti-AIDS viral activity compared to conventional ones by including a new modified oligodeoxyribonucleotide. SOLUTION: This agent contains a compound of formula I {Q is R1R2R3Z [R1 to R3 are each H, a 1-4C alkyl, (substitut ...


7
Kimura Tomio, Katsube Tetsushi, Nishigaki Takashi: Trifluoromethylquinolinecarboxylic acid derivative. Ube Industries, Sankyo, May 14, 1997: EP0773214-A1

This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): (wherein R represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R represents a phenyl group which may be substituted by R, a 5-membered or 6-member ...


8
Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi: Remedies or preventives for aids. Sankyo, liu yuanjin, April 21, 1999: CN97193373

Combined use of one or more drugs selected from among quinolonecarboxylic acid-based anti-HIV agents with one or more drugs selected from among reverse transcriptase inhibitors and HIV protease inhibitors for treating or preventing AIDS; and remedies or preventives for AIDS containing as the active ...


9
Kimura Tomio, Katsube Tetsushi, Nishigaki Takashi: Trifluoromethylquinoline carboxylic acid derivative. Ube Industries, DUAN CHENGEN, June 25, 1997: CN95194136

This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): (wherein R1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R2 represents a phenyl group which may be substituted by R0, a 5-membered or 6-mem ...


10
Ishimura Masako, Nishigaki Takashi: (t) Variants. Sankyo Company, Ishimura Masako, Nishigaki Takashi, OHNO Akio, February 26, 1998: WO/1998/007863

Highly active human interferon $g(t) variants which are useful as preventives or remedies for viral infections, tumors or autoimmune diseases. More particularly, these variants are polypeptides characterized by containing the amino acid sequence represented by SEQ ID NO:8 in the Sequence Listing but ...