1
Nils Lonberg, Robert M Kay: Ransgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend & Townsend & Crew, August 13, 1996: US05545806 (1070 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


2
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Tracy J Dunn, William M Smith, October 29, 1996: US05569825 (951 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies of multiple isotypes. Heterologous antibodies are encoded by immunoglobulin heavy chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, one o ...


3
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, May 27, 1997: US05633425 (910 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies, i.e., antibodies encoded by immunoglobulin heavy and light chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, transgenes encoding unrearr ...


4
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, April 29, 1997: US05625126 (888 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.


5
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Townsend and Townsend and Crew, August 26, 1997: US05661016 (833 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


6
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, June 23, 1998: US05770429 (471 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.


7
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, September 29, 1998: US05814318 (376 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


8
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, August 4, 1998: US05789650 (336 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


9
Harry Meade, Nils Lonberg: Isolation of exogenous recombinant proteins from the milk of transgenic mammals. Biogen, James F Haley Jr, Teresa L Solomon, October 10, 1989: US04873316 (319 worldwide citation)

This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desire ...


10
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Townsend and Townsend and Crew, March 2, 1999: US05877397 (292 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...