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Hofschneider Peter Hans, Wong Tai Kin, Nicolau Yves Claude: Eucaryotic cells and eucaryotic protoplasts with an amount of naked dna introduced by lipid vesicles, process for their preparation and their use in the preparation of gene products.. Max Planck Gesellschaft, April 29, 1981: EP0027662-A1 (23 worldwide citation)

The invention relates to eucaryote cells, eucaryote protoplasts and eucaryote pluricellular living organisms having a certain ADN concentration, introduced by means of lipidic vesicles. Disclosed are a process for the preparation thereof, as well as the use thereof for the preparation of product-gen ...


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Nicolau Yves Claude, Greferath Ruth, Hickman David: Methods and compositions comprising supramolecular constructs. Ac Immune, Nicolau Yves Claude, Greferath Ruth, Hickman David, PRATT John S, September 9, 2005: WO/2005/081872 (23 worldwide citation)

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion pro ...


3
Nicolau Yves Claude Prof Dr, Sene Claude Dr: Process for increasing the incorporation and expression of genetic material in nuclei of intact cells with the aid of liposomes.. Studiengesellschaft Kohle Mbh, January 6, 1982: EP0043075-A2 (17 worldwide citation)

The process is characterised in that endocytosis liposomes which are loaded with genetic material are introduced into the nuclei by means of endocytosis.


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Mouneimne Youssef, Tosi Pierre Francois, Nicolau Yves Claude: Electro-insertion of proteins into animal cell membranes.. Texas A & M Univ Sys, April 11, 1990: EP0362758-A2 (13 worldwide citation)

The present invention concerns a method of incorporating a protein into a cell membrane comprising exposing a cell to an electric field while the cell is suspended in an electro-insertion medium in the presence of a buffered solution (suspension) of the protein(s) to be inserted, the protein bearing ...


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Ropars Claude, Nicolau Yves Claude, Chassaigne Maurice: Process and device for the encapsulation in erythrocytes of at least one biologically active substance, in particular hemoglobin allosteric effectors, and erythrocytes so obtained.. Centre Nat Rech Scient, Hospital Regional de Tours, Studiengesellschaft Kohle Mbh, February 22, 1984: EP0101341-A1 (8 worldwide citation)

L'invention concerne un procédé d'encapsulation dans les érythrocytes humains ou animaux d'au moins une substance présentant une activité biologique, caractérisé en ce que l'on alimente en continu le compartiment primaire (2) d'au moins un élément de dialyse (1) avec une suspension aqueuse d'érythro ...


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Ropars Claude, Nicolau Yves Claude, Chassaigne Maurice: Procede et dispositif pour lencapsulation dans les erythrocytes dau moins une substance a activite biologique, notamment des effecteurs allosteriques de lhemoglobine et erythrocytes ainsi obtenus. Centre Nat Rech Scient, January 6, 1984: FR2529463-A1 (6 worldwide citation)

L'INVENTION CONCERNE UN PROCEDE D'ENCAPSULATION DANS LES ERYTHROCYTES HUMAINS OU ANIMAUX D'AU MOINS UNE SUBSTANCE PRESENTANT UNE ACTIVITE BIOLOGIQUE, CARACTERISE EN CE QUE L'ON ALIMENTE EN CONTINU LE COMPARTIMENT PRIMAIRE D'AU MOINS UN ELEMENT DE DIALYSE AVEC UNE SUSPENSION AQUEUSE D'ERYTHROCYTES, D ...


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Nicolau Yves Claude Prof Dr, Gersonde Klaus Prof Dr: Modified intact erythrocytes, blood or blood preserves containing them and process for their preparation.. Studiengesellschaft Kohle Mbh, Gersonde Klaus Prof Dr, March 21, 1979: EP0001104-A2 (4 worldwide citation)

1. Modified intact erythrocytes ensuring improved oxygen release of the blood, characterized in that allosteric effectors are irreversibly incorporated into the erythrocytes by means of lipid vesicles and these allosteric effectors are bound to the haemoglobin in the erythrocytes.


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Nicolau Yves Claude, Bruggemann Ulrich, Mouneimne Yousef, Roux Eric Conrad: Method and apparatus for encapsulation of biologically-active substances. Cbr Lab, October 13, 2004: EP1466968-A2 (1 worldwide citation)

The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow self-contained electroporation system (10), as shown in the figure which allows withdrawal of blood from a pat ...


10
Nicolau Yves Claude, Greferath Ruth: Methods and compostions of monoclonal antibodies specific for beta-amyloid proteins. Diagenics Internat, August 25, 2004: EP1448601-A2

This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that speci ...