1
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis, Helen Lee, Otis Littlefield, August 13, 2013: US08506966 (33 worldwide citation)

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


2
Mario Contorni, Derek O hagan, Nicola Groth: Influenza vaccines with reduced amounts of squalene. Seqirus, Morrison & Foerster, March 8, 2016: US09278126

Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12 μg/ml per st ...


3
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis Vaccines And Diagnostics, September 3, 2009: US20090220546-A1

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


4
Nicola Groth, Elena Fragapane: Influenza vaccine regimens for pandemic-associated strains. Novartis, April 19, 2012: US20120093859-A1

In contrast to known regimens where pandemic-associated antigens are given 3-4 weeks apart for immunisation, according to the invention two doses of a pandemic-associated antigen are administered to a human 1 week apart, 2 weeks apart or 6 weeks apart. Thus the invention provides a method for immuni ...


5
Mario Contorni, Derek O hagan, Nicola Groth: Influenza vaccines with reduced amounts of squalene. Novartis, March 29, 2012: US20120076822-A1

Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12 μg/ml per st ...


6
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis Vaccines And Diagnostics, February 2, 2012: US20120027813-A1

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...



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