1
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas DP Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt Activity. Merck And Co, November 20, 2008: US20080287457-A1

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


2
Nicholas DP Cosford, Dehua Huang, Nicholas D Smith: Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5. Merck And Co, December 23, 2004: US20040259917-A1

Imidazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar dis ...


3
Nicholas DP Cosford, Chixu Chen, Brian W Eastman, Dehua Huang, Benito Munoz, Petpiboon Prasit, Nicholas D Smith: Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5. Merck And Co, February 3, 2005: US20050026963-A1

Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar diso ...


4
Nicholas DP Cosford, Mark E Layton, Jun Liang, Craig W Lindsley, Philip E Sanderson, Zhijian Zhao: Inhibitors of Akt Activity. Merck And Co, January 10, 2008: US20080009507-A1

The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering ...


5
Mark T Bilodeau, Peter C Chua, Nicholas DP Cosford, Jacob M Hoffman, Johnny Yasuo Nagasawa: Inhibitors of Akt Activity. Merck And Co, November 13, 2008: US20080280889-A1

The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and method ...


6
Ze ev A Ronai, Anindita Bhoumik, Nicholas DP Cosford, Russell Dahl: Compositions and methods for inhibiting growth and metastasis of melanoma. Burnham Institute for Medical Research, Dla Piper, February 26, 2009: US20090054438-A1

There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and ...


7
Nicholas DP Cosford, Dehua Huang, Nicholas D Smith: Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5. Merck And Co, April 21, 2005: US20050085514-A1

Pyrrole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disor ...


8
Nicholas DP Cosford, Petpiboon Prasit, Jeffrey R Roppe, Nicholas D Smith, Lida R Tehrani: Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5. Merck And Co, January 27, 2005: US20050020585-A1

Triazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl which are metabotropic glutamate receptor—subtype 5 (“mGluR5”) modulators useful in the treatment of psychiatric and mood disorders such as, for exampl ...


9
Mark T Bilodeau, Chixu Chen, Nicholas DP Cosford, Brian W Eastman, John C Hartnett, Essa H Hu, Peter J Manley, Lou Anne Neilson, Lida R Tehrani, Zhicai Wu: Inhibitors of Akt Activity. Merck And Co, November 13, 2008: US20080280899-A1

The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer c ...


10
Zéev A Ronai, Anindita Bhoumik, Nicholas DP Cosford, Russell Dahl: Compositions and methods for inhibiting growth and metastasis of melanoma. Burnham Institute for Medical Research, Dla Piper, December 2, 2010: US20100305129-A1

There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and ...



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