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Belleau Bernard, Belleau Pierette, Nguyen Ba Nghe: Substituted -1,3-oxathiolanes with antiviral properties.. Iaf Biochem Int, August 16, 1990: EP0382526-A2 (123 worldwide citation)

Disclosed are compounds of the formula wherein R1 is hydrogen; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is S, S=O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are use of the compounds as antiviral agents, pharmaceutical formulations, an ...


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Belleau Bernard, Dixit Dilop, Nguyen Ba Nghe: 2-substituted-4-substituted-1,3-dioxolanes, synthesis and use thereof.. Iaf Biochem Int, October 18, 1989: EP0337713-A2 (103 worldwide citation)

There is provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.


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Belleau Bernard, Nguyen Ba Nghe: Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis b.. Iaf Biochem Int, July 8, 1992: EP0494119-A1 (87 worldwide citation)

Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.


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Chan Chun Kong Laval, Pereira Ozwy Z, Nguyen Ba Nghe, Reddy Thumkunta Jagadeeswar, Das Sanjoy Kumar, Siddiqui Mohammad Arshad: Thiazole derivatives and their use for the treatment or prevention of flavivirus infections. Shire Biochem, June 25, 2003: EP1321463-A1 (76 worldwide citation)

The present invention provides novel compounds represented by formula I: wherein, for instance, R1 is aryl, Y is carboxy and X is acylamino or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.


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Belleau Bernard, Nguyen Ba Nghe: 1,3-oxathiolanes useful in the treatment of hepatitis.. Iaf Biochem Int, November 25, 1992: EP0515144-A1 (67 worldwide citation)

The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis, in particular hepatitis B.


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Chan Chun, Kong Laval, Liu Bingcan, Nguyen Ba Nghe, Cadilhac Caroline, Turcotte Nathalie: Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase. Virochem Pharma, Chan Chun, Kong Laval, Liu Bingcan, Nguyen Ba Nghe, Cadilhac Caroline, Turcotte Nathalie, OGILVY RENAULT SENCRL, June 29, 2006: WO/2006/066414 (34 worldwide citation)

Bi-or tricyclic compounds of formula (I) wherein R1, R4 and R5 are as herein defined, A represents a single or double bond and two R2, R2’, R3 and R3’ can be joined to form a condensed or spiro ring. These compounds and their pharmaceutical acceptable salt are used in combinations or pharmaceutical ...


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Belleau Bernard, Nguyen Ba Nghe, Belleau Pierette: Substituted-1,3-oxathiolanes with antiviral properties. Iaf Biochem Int, May 15, 1996: EP0711771-A2 (11 worldwide citation)

Disclosed are compounds of the formula wherein R1 is hydrogen; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is S, S=O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are use of the compounds as antiviral agents, pharmaceutical formulations, an ...


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