1
Feng Zhang, Le Cong, Randall Jeffrey Platt, Neville Espi Sanjana, Fei Ran: Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains. The Broad Institute, Massachusetts Institute of Technology, President and Fellows of Harvard College, Vedder Price P C, Thomas J Kowalski, Deborah L Lu, March 31, 2015: US08993233 (41 worldwide citation)

The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the desi ...


2
Feng Zhang, Le Cong, Randall Jeffrey Platt, Neville Espi Sanjana: Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains. The Broad Institute, Maassachusetts Institute of Technology, President and Fellows of Harvard College, Vedder Price P C, Thomas J Kowalski, Deborah L Lu, April 7, 2015: US08999641 (32 worldwide citation)

The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the desi ...


3
Feng Zhang, David Benjamin Turitz Cox, Luciano Marraffini, David Olivier Bikard, Wenyan Jiang, Neville Espi Sanjana: CRISPR-Cas component systems, methods and compositions for sequence manipulation. The Broad Institute, Massachusetts Institute of Technology, The Rockefeller University, Vedder Price P C, Thomas J Kowalski, Deborah L Lu, November 21, 2017: US09822372

The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also ...