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BALESTRA Michael, BURKE Jennifer, CHEN Zhidong, COGAN Derek, FADER Lee, GUO Xin, MCKIBBEN Bryan, MARSHALL Daniel Richard, NEMOTO Peter Allen, YU Hui: [fr] INHIBITEURS DE LALDOSTÉRONE SYNTHASE, [en] ALDOSTERONE SYNTHASE INHIBITORS. BOEHRINGER INGELHEIM INTERNATIONAL, BALESTRA Michael, BURKE Jennifer, CHEN Zhidong, COGAN Derek, FADER Lee, GUO Xin, MCKIBBEN Bryan, MARSHALL Daniel Richard, NEMOTO Peter Allen, YU Hui, MORRIS Michael P, November 6, 2014: WO/2014/179186 (1 worldwide citation)

[en] The present invention relates to compounds of formula (I): I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, mand nare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compoun ...


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Martin Lawrence Leo, Kosley W Raymond Jr, Flanagan M Denise, Kuerzel Gert Ulrich, Nemoto Peter Allen, Wettlaufer David Dr: (substituted) Pyrroles and their use for the treatment of neurodegenerative dysfunctions.. Hoechst Roussel Pharma, February 9, 1994: EP0582182-A1

The present invention relates to compounds of the general formula wherein R1 is hydrogen or loweralkyl; R2 is hydrogen, loweralkyl, hydroxyloweralkyl, acyloxyloweralkyl or loweralkoxyloweralkyl; R3 is hydrogen or loweralkyl; or R2 and R3 taken together form a cycloalkyl ring of 3 to 7 carbon atoms; ...


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Wettlaufer David Gordon, Shutske Gregory Michael, Nemoto Peter Allen: Les 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4-(5h)-ones et ols, procede pour leur preparation et leur utilisation comme medicaments, 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, a process for their preparation and their use as medicaments. Hoechst Roussel Pharmaceuticals, Aventis Pharmaceuticals, BERESKIN & PARR, October 21, 2003: CA2049733

This invention relates to 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and-ols of the formula(see Formula I)wherein X is (see Formula II) or loweralkyl; Y is hydrogen, halogen, loweralkyl,loweralkoxy, trifluoromethyl, nitro or amino; R is H when the bond between the oxygenatom and the carbon ato ...


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Liu Weimin, Gilmore Thomas A, Hickey Eugene Richard, Nemoto Peter Allen, Spero Denice M: Cyanamides useful as reversible inhibitors of cysteine proteases. Boehringer Ingelheim Pharmaceuticals, RAYMOND Robert P, October 23, 2003: WO/2003/086325

Compounds according to the following formula (I): wherein the variables Q and Rl to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathologica ...