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Duncan Robert Armour, Brian Evans, David Middlemiss, Alan Naylor, Neil Anthony Pegg, Maria Victoria Vinader, Gerard Martin Paul Giblin, Tania Hubbard, Michael Menteith Hann, Xiao Qing Lewell, Stephen Paul Watson: Piperidine derivatives. Glaxo Group, Bacon & Thomas, December 30, 1997: US05703240 (8 worldwide citation)

The present invention relates to piperidine derivatives of formula (I) ##STR1## wherein R.sup.1 is a C.sub.1-4 alkoxy group; R.sup.2 is ##STR2## R.sup.3 is a hydrogen or halogen atom; R.sup.4 and R.sup.5 may each independently represent a hydrogen or halogen atom, or a


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Duncan Robert Armour, Brian Evans, David Middlemiss, Tania Hubbard, Michael Menteith Hann, Xiao Qing Lewell, Stephen Paul Watson, Alan Naylor, Neil Anthony Pegg, Maria Victoria Vinader, Gerard Martin Paul Giblin: Piperidine derivatives. Glaxo Group, Bacon & Thomas PLLC, December 1, 1998: US05843966 (5 worldwide citation)

The present invention relates to piperidine derivatives of formula (I) ##STR1## wherein R.sup.1 is a C.sub.1-4 alkoxy group; R.sup.2 is ##STR2## R.sup.3 is a hydrogen or halogen atom; R.sup.4 and R.sup.5 may each independently represent a hydrogen or halogen atom, or a C.sub.1-4 alkyl, C.sub.1-4 alk ...


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Saleh Ahmed, Oscar Barba, Jason Bloxham, Graham Dawson, William Gattrell, John Kitchin, Neil Anthony Pegg, Imaad Saba, Shazia Sadiq, Colin Peter Sambrook Smith, Don Smyth, Amo G Steinig, Robin Wilkes, Bijoy Panicker, Paula Tavares, Matthew Cox, An Hu Li, Hanqing Dong, Lifu Ma, Kenneth, Qinghua, Kathryn Stolz: Substituted pyrrolo[2.3-B]pyridines. OSI Pharmaceuticals, December 16, 2008: US07465726 (4 worldwide citation)

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animal ...


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Andrew Philip Crew, Matthew Cox, Radoslaw Laufer, Neil Anthony Pegg, Colin Peter Sambrook Smith, Yingchuan Sun, Robin David Wilkes, Jonathan Williams: N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library. OSI Pharmaceuticals, September 2, 2008: US07419995 (4 worldwide citation)

Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II): are useful in providing compounds to ...


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Timothy Colin Hancox, Neil Anthony Pegg, Mandy Christine Beswick, Toby Jonathan Blench, Elsa Amandine Dechaux, Jahusz Jozef Kulagowski, Alan John Nadin, Stephen Price: Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase. Genentech, Alex Andrus, May 1, 2012: US08168633 (4 worldwide citation)

Thiazolopyrimidine compounds of formula I, where W represents a thiazole ring, selectively inhibit the p110 delta subtype of PI3 Kinase (PI3K), and are useful for treating diseases and disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase such as cancer, immune ...


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Timothy Colin Hancox, Neil Anthony Pegg, Mandy Christine Beswick, Toby Jonathan Blench, Elsa Amandine Dechaux, Janusz Jozef Kulagowski, Alan John Nadin, Stephen Price: Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase. F Hoffmann La Roche, Alex Andrus, February 22, 2011: US07893060 (2 worldwide citation)

Thiazolopyrimidines of formula (I): wherein W represents a thiazole ring; R1 and R2 form, together with the N atom to which they are attached, a group of the following formula (IIa): in which A is a ring system; m is 0, 1 or 2; R3 is H or C1-C6 alkyl; and R4 is an indole group which is unsubstituted ...