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Kevin Rodzinak
Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Leff Matthew A, December 10, 2009: WO/2009/148916 (10 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods ...


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Naya Akira, Owada Yufu, Saeki Toshihiko, Ohwaki Kenji, Iwasawa Yoshikazu: Chemokine receptor antagonists. Banyu Pharma, May 19, 1999: EP0916668-A1 (16 worldwide citation)

The present invention relates to a compound of the general formula: wherein each of R and R which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower alkyl group, X is an oxygen atom, a sulfur atom or CH, Y is CH or a nitrogen atom, and A is e.g. a 1-substituted-4-piperi ...


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Otake Norikazu, Haga Yuji, Naya Akira, Mizutani Sayaka, Kanatani Akio: (Ja) ピリドン誘導体, (En) Pyridone derivative. Banyu Pharmaceutical, Otake Norikazu, Haga Yuji, Naya Akira, Mizutani Sayaka, Kanatani Akio, ODAJIMA Heikichi, September 15, 2005: WO/2005/085200 (14 worldwide citation)

(EN) Disclosed is a pyridone derivative represented by the following formula (I). [In the formula, R1 and R2 may be the same or different and respectively represent H or the like, or alternatively R1 and R2 may form an aliphatic nitrogen-containing heterocyclic group together with N to which they ar ...


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Ohtake Norikazu, Naya Akira, Haga Yuji, Jitsuoka Makoto, Suga Takuya, Yoshimoto Ryo, Tokita Shigeru, Kanatani Akio: (Ja) ヘテロアリールオキシ含窒素飽和へテロ環誘導体, (En) Heteroaryloxy nitrogenous saturated heterocyclic derivative. Banyu Pharmaceutical, Ohtake Norikazu, Naya Akira, Haga Yuji, Jitsuoka Makoto, Suga Takuya, Yoshimoto Ryo, Tokita Shigeru, Kanatani Akio, BANYU PHARMACEUTICAL, January 27, 2005: WO/2005/007644 (12 worldwide citation)

(EN) Compound of the formula: (I) [wherein each of X1, X2 and X3 independently represents N or CH, W represents the formula (II): (II) or the formula (III): (III) and Y represents a group of the formula (IV): (IV) ], or a pharmacologically acceptable salt thereof. This compound exhibits histamine re ...


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Yamakawa Takeru, Ogino Yoshio, Sagara Yufu, Matsuda Kenji, Naya Akira, Kimura Toshifumi, Otake Norikazu: Benzimidazolone derivatives. Banyu Pharma, February 4, 2004: EP1386920-A1 (11 worldwide citation)

This invention relates to benzimidazolone derivatives, represented by compounds of a general formula ÄIÜ Äin which R and R stand for, e.g., hydrogen atoms; R, R, R, R stand for, e.g., hydrogen atoms and alkyl groups; R stands for e.g., aryl or heteroaryl groups; A ring stands for 5- to 8-membered al ...


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Naya Akira, Sakamoto Toshihiro, Haga Yuji, Otake Norikazu: (Ja) フェニルピリドン誘導体, (En) Phenylpyridone derivative. Banyu Pharmaceutical, Naya Akira, Sakamoto Toshihiro, Haga Yuji, Otake Norikazu, BANYU PHARMACEUTICAL, March 1, 2007: WO/2007/024004 (8 worldwide citation)

(EN) A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together with a nitrogen atom to which L, Z2 and R1 are attached may form an aliphatic nitrogenated heterocyclic grou ...


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Otake Norikazu, Haga Yuji, Naya Akira, Mizutani Sayaka, Kanatani Akio: Pyridone derivative. Banyu Pharma, January 10, 2007: EP1741703-A1 (7 worldwide citation)

The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R 1 and R 2 may be same or different and stands for H, etc., or R 1 and R 2 may form an aliphatic nitrogen-containing heterocyclic group together with the N to which they bind; X 1 -X 3 may be same or d ...


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Ohtake Norikazu, Naya Akira, Haga Yuji, Jitsuoka Makoto, Suga Takuya, Yoshimoto Ryo, Tokita Shigeru, Kanatani Akio: Heteroaryloxy nitrogenous saturated heterocyclic derivative. Banyu Pharma, April 5, 2006: EP1642898-A1 (1 worldwide citation)

Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): or the following formula (III): Y represents a group of a formula (IV): The compounds have a histamine-H3 receptor ...


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Otake Norikazu, Haga Yuji, Naya Akira, Mizutani Sayaka, Kanatani Akio: Derive pyridone, Pyridone derivative. Banyu Pharmaceutical, Banyu Pharmaceutical, Ogilvy Renault Sencrl, February 15, 2011: CA2558272 (1 worldwide citation)

The invention provides pyridone derivatives represented by a general formula (I). (see formula I)in the formula, R1 and R2 may be the same or different and stands for H. etc., or R1 and R2 form an aliphatic nitrogen-containing heterocyclic group together with N to which they bind; X1-X3 may be the s ...



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