1
Paul W Wedeking, Ruth E Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E Linder, Ramachandran S Ranganathan, Adrian D Nunn, Natarajan Raju, Michael F Tweedle: Metal complexes derivatized with folate for use in diagnostic and therapeutic applications. Bracco Research USA, Imre Balogh, July 25, 2000: US06093382 (55 worldwide citation)

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand ...


2
Mathew A Von Wronski, Edmund R Marinelli, Adrian D Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju: Compounds for targeting endothelial cells, compositions containing the same and methods for their use. Bracco International, Kramer Levin Naftalis & Frankel, September 19, 2006: US07109167 (27 worldwide citation)

The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions usef ...


3
Kondareddiar Ramalingam, Natarajan Raju: Heteroatom-bearing ligands and metal complexes thereof. Bracco International, George P Hoare, Donald L Rhoads, March 4, 1997: US05608110 (25 worldwide citation)

Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.


4
Kondareddiar Ramalingam, Natarajan Raju: Polyaza heteroatom-bearing ligands and metal complexes thereof for imaging or radiotherapy. Bracco International, George P Hoare, Donald L Rhoads, August 12, 1997: US05656254 (22 worldwide citation)

Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.


5
Paul W Wedeking, Ruth E Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E Linder, Ramachandran S Ranganathan, Adrian D Nunn, Natarajan Raju, Michael F Tweedle: Metal complexes derivatized with folate for use in diagnostic and therapeutic applications. Bracco Research USA, Imre Balogh, April 24, 2001: US06221334 (22 worldwide citation)

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, an ...


6
Kondareddiar Ramalingam, Natarajan Raju: Heteroatom-bearing ligands and metal complexes thereof. Bracco International, George P Hoare, Donald L Rhoads, September 9, 1997: US05665329 (19 worldwide citation)

Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.


7
Kondareddiar Ramalingam, Natarajan Raju: Heteroatom-bearing ligands and metal complexes thereof. Bracco International, George P Hoare, Donald L Rhoads, May 6, 1997: US05627286 (19 worldwide citation)

Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.


8
Enrico Cappelletti, Luciano Lattuada, Karen E Linder, Edmund R Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E Swenson, Michael Tweedle: Gastrin releasing peptide compounds. Bracco Imaging S p A, Kramer Levin Naftali & Frankel, June 5, 2007: US07226577 (9 worldwide citation)

New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N-O-P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or ...


9
Enrico Cappelletti, Luciano Lattuada, Karen E Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E Swenson, Michael Tweedle: Gastrin releasing peptide compounds. Bracco Imaging S p A, Kramer Levin Naftalis & Frankel, November 3, 2009: US07611692 (5 worldwide citation)

New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patien ...


10
Enrico Cappelletti, Luciano Lattuada, Karen E Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian D Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E Swenson, Michael F Tweedle: Gastrin releasing peptide compounds. Bracco Imaging S p A, Kramer Levin Naftalis & Frankel, December 14, 2010: US07850947 (4 worldwide citation)

New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are define herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha ...