1
Carl W Gilbert, Myung Ok Cho: Interferon polymer conjugates. Enzon, Roberts & Mercanti, January 27, 1998: US05711944 (128 worldwide citation)

A process is disclosed for preparing long-acting alpha interferon-containing compositions. Alpha interferon is contacted with a relatively small molar excess of a substantially non-antigenic polymer in the presence of a surfactant to preserve bioactivity. Isolation of the desired conjugate species h ...


2
Robert G L Shorr, Carl W Gilbert, Brian M Martin, Myung Ok Cho, Edward J Ginns: Glycolipid enzyme-polymer conjugates. The United States of America represented by The Department of Health and Human Services, January 6, 1998: US05705153 (10 worldwide citation)

Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have ...


3
Robert G L Shorr, Myung Ok Cho, Carl W Gilbert, Edward J Ginns, Brian M Martin: Glycolipid enzyme-polymer conjugates. Enzon, Michael N Mercanti, April 15, 1997: US05620884 (3 worldwide citation)

Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have ...