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John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (95 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


2
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (75 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


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John E Starrett Jr, Muzammil M Mansuri, David R Tortolani: Retinoid-like compounds. Bristol Myers Squibb Company, William T Han, June 4, 1996: US05523457 (42 worldwide citation)

This invention relates to a retinoid mpound of formula I ##STR1## in which Y is --CO--NH--, --CR.sup.2 .dbd.CR.sup.3 --, --CO--O--, --O--CO--, --C(.dbd.S)--NH--, --C.tbd.C--, --O--CH.sub.2 --, --CH.sub.2 --O--, or --CH.sub.2 --CH.sub.2 --;


5
Muzammil M Mansuri, Krishna K Murthi, Kollol Pal: Inhibitors of cyclin dependent kinases. Mitotix, Foley Hoag & Eliot, March 31, 1998: US05733920 (35 worldwide citation)

The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These compounds can be used for inhibiting excessive or abnormal cell proliferation. Thus, the novel compoun ...


6
Muzammil M Mansuri, John C Martin, Thomas W Hudyma, Joanne J Bronson, Louis M Ferrara: Phosphonomethoxy carbocyclic nucleosides and nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Mark L Bosse, April 28, 1998: US05744600 (27 worldwide citation)

A compound of the Formula I or Formula II ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, ...


7
John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Company, David M Morse, April 8, 1997: US05618839 (20 worldwide citation)

The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which


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John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Co, David M Morse, July 15, 1997: US05648385 (19 worldwide citation)

The present invention relates to a compound of formula ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which


9
John E Starrett Jr, Muzammil M Mansuri, John C Martin, Carl E Fuller, Henry G Howell: Production of 2,3-dideoxy-2,3-didehydronucleosides. Bristol Myers Company, Robert E Carnahan, February 27, 1990: US04904770 (15 worldwide citation)

There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficie ...


10
Roman Z Sterzycki, Muzammil M Mansuri, John C Martin: 2,3-dideoxy-2-fluoroarabinopyrimidine nucleosides. Bristol Myers Company, Robert E Carnahan, March 13, 1990: US04908440 (12 worldwide citation)

There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.



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