1
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (63 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


2
Souda Shigeru, Ueda Norihiro Mezon Gakuen, Miyazawa Shuhei, Tagami Katsuya, Nomoto Seiichiro, Okita Makoto, Shimomura Naoyuki, Kaneko Toshihiko Sejuru Kasuga, Fujimoto Masatoshi, Murakami Manabu, Oketani Kiyoshi, Fujisaki Hideaki, Shibata Hisashi, Wakabayashi Tsuneo: Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same.. Eisai, June 1, 1988: EP0268956-A2 (49 worldwide citation)

The invention provides pyridine derivatives represented by general formula: wherein R and R may be the same or different from each other and each stand for a hydrogen atom, a lower alkyl, lower alkoxy, halogenated lower alkyl, lower alkoxycarbonyl or carboxyl group or a halogen atom; X stands for a ...


3
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


4
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


5
Murakami Manabu, Nagai Koichi: Optical head. Toshiba, February 14, 2003: JP2003-045068 (10 worldwide citation)

PROBLEM TO BE SOLVED: To provide an optical head which accurately adjusts the distances of lens group for compensating a spherical aberration. SOLUTION: The optical head is characterized by the fact that the optical head is provided with a relay lens system 6 which compensates the spherical aberrati ...


6
Souda Shigeru, Ueda Norihiro, Miyazawa Shuhei, Tagami Katsuya, Nomoto Seiichiro, Okita Makoto, Shimomura Naoyuki, Kaneko Toshihiko, Fujimoto Masatoshi, Murakami Manabu, Oketani Kiyoshi, Fujisaki Hideaki, Shibata Hisashi, Wakabayashi Tsuneo: Pyridine derivative and therapeutic agent for ulcer comprising the same.. Eisai, December 21, 1988: EP0295603-A1 (9 worldwide citation)

A pyridine compound having the formula is disclosed and useful to treat the peptic ulcer. wherein R and R which may be the same or different are each a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogenated lower alkyl group, or a halogen atom, R and R which may be the same or diffe ...


7
Murakami Manabu, Yamashita Masanori, Mikoshi Tadafumi, Fujii Akihiko: Industrial robot for pressing system, pressing system, and method for bending plate material.. Daikin, February 14, 1990: EP0354559-A1 (8 worldwide citation)

An industrial robot (2), designed for use in a press brake system, has a holding member (5) for holding a plate shaped material (3), a base arm (22, 32, 42), and a working arm (W). The holding member (H) nearly follows the plate shaped material (3) without holding during a pressing process of the pr ...


8
Souda Shigeru, Ueda Norihiro, Miyazawa Shuhei, Tagami Katsuya, Nomoto Seiichiro, Okita Makoto, Shimomura Naoyuki, Kaneko Toshihiko, Fujimoto Masatoshi, Murakami Manabu, Oketani Kiyoshi, Fujisaki Hideaki, Shibata Hisashi, Wakabayashi Tsuneo: Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same.. Eisai, May 24, 1995: EP0654471-A1 (8 worldwide citation)

The invention provides pyridine derivatives represented by general formula: wherein R and R may be the same or different from each other and each stand for a hydrogen atom, a C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, (C1-6 alkoxy)carbonyl or carboxyl group or a halogen atom; X stands for a gr ...


9

10
Souda Shigeru, Wakabayashi Tsuneo, Nomoto Seiichiro, Tagami Katsuya, Okita Makoto, Shimomura Naoyuki, Kaneko Toshihiko, Oketani Kiyoshi, Fujisaki Hideaki, Shibata Hisashi, Fujimoto Masatoshi, Ueda Norihiro, Miyazawa Shuhei, Murakami Manabu: Derive de pyridine pour le traitement des ulceres, Pyridine derivative having anti-ulcerative activity. Eisai, SMART & BIGGAR, January 30, 1990: CA1265138 (2 worldwide citation)

65702-288 ABSTRACT Novel pyridine derivatives of formula Image (wherein R1 and R2 are H, alkyl, alkoxy, halogenated alkyl, alkoxy-carbonyl, carboxyl or halogen; X is -O-, -S or -NR3- [where R3 is H, alkyl, phenyl, benzyl or alkoxycarbonyl], Z is O(CH2)pOR4 [where R4 is H, alkyl, aryl or aralkyl and ...