1
Murty N Vyakarnam, Mark C Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C Melican, Clairene A Bazilio, Mark B Roller, David V Gorky: Foam composite for the repair or regeneration of tissue. Ethicon, October 23, 2001: US06306424 (270 worldwide citation)

The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable ...


2
Pamela L Plouhar, Prasanna Malaviya, Joe W Ferguson, Mora C Melican: Reinforced small intestinal submucosa (SIS). DePuy Orthopaedics, Barnes & Thornburg, October 28, 2003: US06638312 (127 worldwide citation)

A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of s ...


3
Pamela L Plouhar, Prasanna Malaviya, Joe W Ferguson, Mora C Melican: Reinforced small intestinal submucosa. DePuy Orthopaedics, Barnes & Thornburg, January 9, 2007: US07160333 (113 worldwide citation)

Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.


4
Kelly R Brown, Iksoo Chun, Joseph J Hammer, Victor F Janas, Jennifer Mandanas, Mora C Melican, Alireza Rezania, Mark C Zimmerman: Implantable biodegradable devices for musculoskeletal repair or regeneration. Ethicon, March 20, 2007: US07192604 (49 worldwide citation)

An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is pro ...


5
Iksoo Chun, Yufu Li, Mora C Melican: Methods of making micropatterned foams. Ethicon, July 23, 2002: US06423252 (43 worldwide citation)

The present invention is directed to a method of making a foam, the method including contacting a polymer solution with a surface of a mold, the solution containing dissolved therein a biocompatible polymer, the mold containing disposed on at least one surface thereof a three-dimensional negative co ...


6
Murty N Vyakarnam, Mark C Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C Melican, Clairene A Bazilio, Mark B Roller, David V Gorky: Foam composite for the repair or regeneration of tissue. Ethicon, September 26, 2006: US07112417 (38 worldwide citation)

The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable ...


7
Laura Jean Brown, Iksoo Chun, Sridevi Dhanaraj, Prasanna Malaviya, Mora C Melican, Alireza Rezania, Li Zhang: Hybrid biologic-synthetic bioabsorbable scaffolds. DePuy Products, Barnes & Thornburg, February 5, 2013: US08366787 (29 worldwide citation)

A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion com ...


8
Debra A Timm, Henry K Hui, Mark B Roller, Mora C Melican, Syed Hossainy: Sterilization of bioactive coatings. Ethicon, September 7, 2004: US06787179 (28 worldwide citation)

The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or i ...


9
Prasanna Malaviya, Mora C Melican, Alireza Rezania, Iksoo Chun: Hybrid biologic/synthetic porous extracellular matrix scaffolds. DePuy Products, Barnes & Thornburg, March 29, 2011: US07914808 (19 worldwide citation)

Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slu ...


10
Aruna Nathan, Mora C Melican, Kelly R Brown, Mark C Zimmerman: Bone replacement materials utilizing bioabsorbable liquid polymers. Ethicon, February 28, 2006: US07005136 (12 worldwide citation)

The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than ab ...