1
Busch Brett B, Flatt Brenton T, Gu Xiao Hui, Lu Shao Po, Martin Richard, Mohan Raju, Nyman Michael Charles, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong: Pyrazole based lxr modulators. Exelixis, Busch Brett B, Flatt Brenton T, Gu Xiao Hui, Lu Shao Po, Martin Richard, Mohan Raju, Nyman Michael Charles, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong, GREENFIELD Michael S, January 4, 2007: WO/2007/002559 (57 worldwide citation)

Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containi ...


2
Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J: Isoquinolinone derivatives and their use as therapeutic agents. X Ceptor Therapeutics, Sankyo Company, Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J, ROTH Carol J, July 15, 2004: WO/2004/058717 (47 worldwide citation)

This invention is directed to isoquinolinone derivatives and their use in modulating the activity of orphan nuclear receptors, pharmaceutical compositions containing such derivatives, and methods of using such derivatives in treating disease-states associated with nuclear receptor activity.


3

4
Boren Brant Clayton, Busch Brett B, Gu Xiao Hui, Jammalamadaka Vasu, Lu Shao Po, Martin Richard, Mohan Raju, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong, Xu Wei: Lxr and fxr modulators. Exelixis, Boren Brant Clayton, Busch Brett B, Gu Xiao Hui, Jammalamadaka Vasu, Lu Shao Po, Martin Richard, Mohan Raju, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong, Xu Wei, GREENFIELD Michael S, June 19, 2008: WO/2008/073825 (23 worldwide citation)

Compounds of the invention are disclosed, such as compounds of formulae LX - LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1 ...


5
Bryant Judi, Buckman Brad, Islam Imadul, Mohan Raju, Morrissey Michael, Wei Guo Ping, Xu Wei, Yuan Shendong: 2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists. Schering Aktiengesellschaft, Bryant Judi, Buckman Brad, Islam Imadul, Mohan Raju, Morrissey Michael, Wei Guo Ping, Xu Wei, Yuan Shendong, HERMENAU Ronald S, June 24, 2004: WO/2004/052366 (10 worldwide citation)

Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compoun ...


6
Busch Brett B, Flatt Brenton T, Gu Xiao Hui, Lu Shao Po, Martin Richard, Mohan Raju, Nyman Michael Charles, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong: Imidazole based lxr modulators. Exelixis, Busch Brett B, Flatt Brenton T, Gu Xiao Hui, Lu Shao Po, Martin Richard, Mohan Raju, Nyman Michael Charles, Schweiger Edwin, Stevens William C Jr, Wang Tie Lin, Xie Yinong, GREENFIELD Michael S, January 4, 2007: WO/2007/002563 (9 worldwide citation)

Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing ...


7
Flatt Brenton, Gu Xiao Hui, Martin Richard, Mohan Raju, Murphy Brett, Nyman Michael C, Stevens William C Jr, Wang Tie Lin: Heterocyclic carboxamide compounds as steroid nuclear receptors ligands. Exelixis, Flatt Brenton, Gu Xiao Hui, Martin Richard, Mohan Raju, Murphy Brett, Nyman Michael C, Stevens William C Jr, Wang Tie Lin, GREENFIELD Michael S, July 20, 2006: WO/2006/076202 (8 worldwide citation)

Heterocyclic carboxamide compounds are described herein as being useful in modulating the activity of steroid nuclear receptors. Pharmaceutical compositions containing the compounds, methods of using the compounds and processes for making the compounds are also described.


8
Busch Brett, Johnson Alan T, Martin Richard, Mohan Raju, Stevens William C Jr: 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders. X Ceptor Therapeutics, Busch Brett, Johnson Alan T, Martin Richard, Mohan Raju, Stevens William C Jr, ROTH Carol J, August 11, 2005: WO/2005/072731 (8 worldwide citation)

Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the e ...


9
Martin Richard, Mohan Raju, Busch Brett B, Nyman Michael Charles, Stevens William C Jr: Pharmaceutical compositions. Exelixis, Martin Richard, Mohan Raju, Busch Brett B, Nyman Michael Charles, Stevens William C Jr, ESKTROM Carmen P, May 4, 2006: WO/2006/047269 (7 worldwide citation)

Compounds for use in compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the estrogen related receptors are provided. In one embodiment, the compounds provided herein are ERR modulators. I ...


10