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De Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Vreysen Eduard Jozef Constanti: Process for preparing enantiomerically pure imidazo not 4,5,1-jk - not 1,4 -benzodiazepin-2(1h)-thiones. Janssen Pharmaceutica, March 31, 1993: EP0534539-A1 (3 worldwide citation)

Process for preparing enantiomerically pure imidazoÄ4,5,1-jkÜÄ1,4Übenzodiazepin-2(1H)-thiones of formula starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) Novel enantiomerically pure intermediates of formula (III) and (IV) prepared in the cour ...


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Heeres Jan, Lewi Paulus Joannes, Leemans Rudolf, Moens Luc Jozef Raphael, Janssen Paul Adriaan Jan: Hiv inhibiting 2-( 4-cyanophenylamino) pyrimidine derivatives. Tibotec Pharmaceuticals, Heeres Jan, Lewi Paulus Joannes, Arts Frank Xavier Jozef Herwig, Leemans Rudolf, Moens Luc Jozef Raphael, WANTE Dirk, August 3, 2006: WO/2006/079656 (1 worldwide citation)

HIV replication inhibitors of formula (I) pharmaceut ically acceptable addition salts or stereochemically isomeric forms thereof, wherein X is NR4, S, SO or SO2; the preparation of these compounds as well as pharmaceutical compositions comprising these compounds; the use of these compounds for the p ...


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HEERES JAN, LEWI PAULUS JOANNES, JANSSEN PAUL ADRIAAN JAN, LEEMANS RUDOLF, MOENS LUC JOZEF RAPHAEL: HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives, HIV-inhibierende 2-(4-cyanophenylamino)Pyrimidinderivate, Derives de 2-(4-cyanophenyl)pyrimidine utiles pour inhiber le VIH. TIBOTEC PHARM, November 23, 2011: EP2388249-A1

HIV replication inhibitors of formula pharmaceutically acceptable addition salts or stereochemically isomeric forms thereof, wherein X is S, SO or SO 2 the preparation of these compounds as well as pharmaceutical compositions comprising these compounds the use of these compounds for the prevention o ...


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Janssen Paul Adriaan Jan, Heeres Jan, Lewi Paulus Joannes, Leemans Rudolf, Moens Luc Jozef Raphael: Hiv inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives. Tibotec Pharm, liudong fanchi, January 16, 2008: CN200680003109

HIV replication inhibitors of formula (I) pharmaceut ically acceptable addition salts or stereochemically isomeric forms thereof, wherein X is NR, S, SO or SO2; the preparation of these compounds as well as pharmaceutical compositions comprising these compounds; the use of these compounds for the pr ...


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De Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Rey Max: Synthese de cisapride, Synthesis of cisapride. Janssen Pharmaceutica, Janssen Pharmaceutica, GOWLING LAFLEUR HENDERSON, April 23, 1998: CA2263692

This invention concerns a new process of preparing cisapride, and the pharmaceutically acceptable acid addition salts thereof, by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent, yielding 1-[3-(4- ...


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De, Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Vreysen Eduard Jozef Constantia: Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]-benzodiazepin-2(1h^_)-thiones. Janssen Pharmaceutica, de, Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Vreysen Eduard Jozef Constantia, WANTE Dirk, April 1, 1993: WO/1993/006106

Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H^_)-thiones of formula (I), starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N^_-protected 1,2-diaminopropanes (III). Novel enantiomerically pure intermediates of formulas (III) and (IV) prepared ...


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De, Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Rey Max: Synthesis of cisapride. Janssen Pharmaceutica, de, Knaep Alfons Gaston Maria, Moens Luc Jozef Raphael, Rey Max, QUAGHEBEUR Luc, April 23, 1998: WO/1998/016511

This invention concerns a new process of preparing cisapride, and the pharmaceutically acceptable acid addition salts thereof, by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent, yielding 1-[3-(4- ...


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