11
Mitchell E Reff, William S Kloetzer, Takehiko Nakamura: γ-1 anti-human CD23 monoclonal antibodies and use thereof as therapeutics. Biogen Idec MA, Pillsbury Winthrop, April 25, 2006: US07033589 (26 worldwide citation)

Methods for inhibiting production of IgE in a human subject with an IgE-mediated allergic disorder by administering anti-CD23 antibodies.


12
Mitchell E Reff, Richard Spence Barnett, Karen Retta McLachlan: Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same. IDEC Pharmaceuticals Corporation, Burns Doane Swecker & Mathis, November 3, 1998: US05830698 (26 worldwide citation)

A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site pre ...


13
Darrell R Anderson, Nabil Hanna, John E Leonard, Roland A Newman, Mitchell E Reff, William H Rastetter: Expression and use of anti-CD20 Antibodies. Biogen Idec, Sidley Austin, June 29, 2010: US07744877 (11 worldwide citation)

Disclosed herein are methods of depleting peripheral blood B cells in a human host comprising administering to the host an immunologically active anti-CD20 antibody in an amount effective to deplete peripheral blood B cells in the host.


14
Darrell R Anderson, Nabil Hanna, Roland A Newman, Mitchell E Reff, William H Rastetter: Expression and use of anti-CD20 antibodies. Biogen Idec, Sidley Austin, June 3, 2008: US07381560 (10 worldwide citation)

Disclosed are immunologically active antibodies directed against the CD20 antigen, as well as host cells comprising nucleic acid sequences encoding the light chains and heavy chains of immunologically active antibodies wherein the cell is capable of expressing and secreting an immunologically active ...


15
Mitchell E Reff: Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same. IDEC Pharmaceuticals Corporation, Burns Doane Swecker & Mathis L, January 25, 2000: US06017733 (6 worldwide citation)

Disclosed herein are fully impaired consensus Kozak sequences which are most typically used with dominant selectable markers of transcriptional cassettes which are a part of an expression vector, These vectors are most typically utilized in the expression of proteins in mammalian expression systems. ...


16
Mitchell E Reff, William S Kloetzer, Takehiko Nakamura: Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics. Biogen Idec MA, Pillsbury Winthrop, May 17, 2005: US06893636 (3 worldwide citation)

Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practic ...


17
Mitchell E Reff, William S Kloetzer, Takehiko Nakamura: Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics. Biogen Idec MA, Pillsbury Winthrop Shaw Pittman, May 29, 2007: US07223392 (2 worldwide citation)

Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practic ...


18
Mitchell E Reff, William S Kloetzer, Takehiko Nakamura: Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics. Biogen Idec MA, Pillsbury Winthrop Shaw Pittman, October 21, 2008: US07438906 (1 worldwide citation)

Methods for inhibiting production of IgE in a human subject with an IgE-mediated allergic disorder by administering anti-CD23 antibodies.


19
Mitchell E Reff, William S Kloetzer, Takehiko Nakamura: Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics. Biogen Idec, Pillsbury Winthrop Shaw Pittman, February 19, 2008: US07332163 (1 worldwide citation)

Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practic ...


20
Eric N Ailor, Mitchell E Reff: Method to increase protein production in culture. Sterne Kessler Goldstein & Fox Pllc, May 19, 2005: US20050106222-A1 (1 worldwide citation)

A new recombinant protein production methodology has been discovered for expression of genes of interest. This should be useful for low or poorly expressing genes and in cellular production of high levels of proteins when such high levels may be detrimental or stressful to cells. Isolated polynucleo ...