1
Kevin Rodzinak
Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Leff Matthew A, December 10, 2009: WO/2009/148916 (10 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods ...


2

3
Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Merck & Co, December 10, 2009: WO/2009/148887 (8 worldwide citation)

The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibi ...


4
Ohkubo Mitsuru, Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Shimomura Toshiyasu: Novel aminopyridine derivatives having aurora a selective inhibitory action. Banyu Pharmaceutical, Ohkubo Mitsuru, Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Shimomura Toshiyasu, BANYU PHARMACEUTICAL, May 4, 2006: WO/2006/046735 (6 worldwide citation)

The present invention relates to a compound represented by the general formula (I): wherein Ra and Rb are each independently hydrogen atom or lower alkyl, or alternatively Ra and Rb are combined together to form -CH2 -; Rc is halogen atom; Rd is halogen atom or methyl substituted with one to three h ...


5
Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Nonoshita Katsumasa, Ohkubo Mitsuru: Novel aminopyridine derivatives having aurora a selective inhibitory action. Banyu Pharmaceutical, Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Nonoshita Katsumasa, Ohkubo Mitsuru, BANYU PHARMACEUTICAL, August 27, 2009: WO/2009/104802 (3 worldwide citation)

The present invention relates to a compound of formula I:wherein: R1 is a hydrogen atom, F, CN, etc.; R2 is CO, SO2, etc.; R3 is a phenyl which may be substituted; X1, X2, and X3 each independently CH, N, etc. provided, however, that among X1, X2 and X3, the number of nitrogen is 0 or 1; W is the fo ...


6
Nishihara Akinori, Hasebe Tetsuya, Hayashi Hiroaki, Mita Takashi: Arithmetic system. Tokyo Electron Device, Nishihara Akinori, January 31, 2003: JP2003-029969 (2 worldwide citation)

PROBLEM TO BE SOLVED: To directly realize the performance of a large scale program composed of a plurality of program modules by hardware without using a general purpose CPU.SOLUTION: For a gate array 42, logical constitution among gate circuits 42a is attained according to an FPGA data module store ...


7
Ohkubo Mitsuru, Kato Tetsuya, Kawanishi N, Mita Takashi, Shimomura T: Novel aminopyridine derivatives having selective aurora-a inhibitory effect. Banyu Pharma, August 1, 2007: EP1813609-A2 (2 worldwide citation)

The present invention relates to a compound represented by the general formula (I): wherein m 1 and m 2 are 1, 2, or 3; n 1 and n 2 are 0 or 1; i is an integer of any of 1 to m 1 ; j is an integer of 1 to m 2 ; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; R ai and R ai ' is ...


8
SAKAMOTO Toshihiro, MITA Takashi, SHIBATA Kazuaki, OGINO Yoshio, KOMATANI Hideya: [ja] 1,2,4-トリアジン-6-カルボキサミド誘導体, [fr] DÉRIVÉ DE 1,2,4-TRIAZINE-6-CARBOXAMIDE, [en] 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE. TAIHO PHARMACEUTICAL, THE PATENT CORPORATE BODY ARUGA PATENT OFFICE, April 4, 2013: WO/2013/047813 (2 worldwide citation)

[en] A compound represented by general formula (I), or a salt thereof, having a Syk inhibitory effect. (In the formula, R1 represents a hydrogen atom or C1-C6 alkyl group optionally substituted by Ra; A represents a hydrogen atom, C1-C8 alkyl group optionally substituted by Ra, C2-C6 alkenyl group o ...


9
Mita Takashi, Nishihara Akinori: Operating system. Tokyo Electron Device, Nishihara Akinori, July 11, 2003: JP2003-198362 (1 worldwide citation)

PROBLEM TO BE SOLVED: To realize efficient execution of a large scale program comprising a plurality of program modules directly by means of hardware without using a general purpose CPU.SOLUTION: A gate array 43 performs operation by means of hardware according to an FPGA data module stored in an FP ...


10
Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Ohkubo Mitsuru, Shimomura Toshiyasu: (Ja) オーロラa選択的阻害作用を有する新規アミノピリジン誘導体, (En) Novel aminopyridine derivative having selective aurora-a inhibitory activity. Banyu Pharmaceutical, Kato Tetsuya, Kawanishi Nobuhiko, Mita Takashi, Ohkubo Mitsuru, Shimomura Toshiyasu, BANYU PHARMACEUTICAL, December 7, 2006: WO/2006/129842 (1 worldwide citation)

(EN) A compound represented by the general formula [I]: (I) [wherein m1 and m2 each is 1, 2, or 3; n1 and n2 each is 0 or 1; i is an integer of 1 to m1; j is an integer of 1 to m2; R is optionally substituted aryl, heteroaryl, or cycloalkyl; Rai and Rai' each is hydrogen, etc.; Rbj and Rbj' each is ...



Click the thumbnails below to visualize the patent trend.