1
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


2
Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Nitrogenous heterocyclic compound and medicine thereof. Eisai, December 8, 2004: EP1484327-A1 (6 worldwide citation)

Compounds represented by the following general formula: Äwherein X, X, X and X each independently represent a single bond, C1-6 alkylene, etc.; A represents optionally substituted phenyl, etc.; A represents an optionally substituted 5- to 7-membered heterocyclic group containing -C(=Q)- (wherein Q r ...


3
ASANO OSAMU, HARADA HITOSHI, YOSHIKAWA SEIJI, WATANABE NOBUHISA, INOUE TAKASHI, HORIZOE TATSUO, YASUDA NOBUYUKI, OHASHI KAYA, MINAMI HIROE, NAGAOKA JUNSAKU, MURAKAMI MANABU, KOBAYASHI SEIICHI, TANAKA ISAO, KAWATA TSUTOMU, SHIMOMURA NAOYUKI, AKAMATSU HIROSHI, OZEKI NAOKI, SHIMIZU TOSHIKAZU, HAYASHI KENJI, HAGA TOYOKAZU, NEGI SHIGETO, NAITO TOSHIHIKO: COMPOSES IMIDAZOLE FUSIONNES ET MEDICAMENTS CONTRE LE DIABETE SUCRE, CONDENSED IMIDAZOLE COMPOUNDS AND A THERAPEUTIC AGENT FOR DIABETES MELLITUS. EISAI, EISAI R&D MANAGEMENT, SMART & BIGGAR, September 15, 2009: CA2376835

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


4
Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Azote contenant des composes heterocycliques et medicaments ainsi constitues, Nitrogen containing heterocyclic compounds and medicines containing the same. Eisai, Eisai R&D Management, MARKS & CLERK, October 16, 2003: CA2477839

Compounds represented by the following general formula: (see formula I) [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containin ...


5

6
Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Nitrogenous heterocyclic compound and medicine thereof. Eisai, HASEGAWA Yoshiki, October 16, 2003: WO/2003/084948

A compound represented by the general formula (I), a salt thereof, or a hydrate of either: (I) wherein X1, X2, X3, and X4 each independently means a single bond, C1-6 alkylene, etc.; A2 means optionally substituted phenyl, etc.; A1 means an optionally substituted group represented by -C(=Q1)- [where ...


7
Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Nitrogenous heterocyclic compound and medicine thereof. Eisai R&Amp Amp D Management, December 31, 2004: KR1020047014370

A compound represented by the general formula (I), a salt thereof, or a hydrate of either: (I) wherein X 1, X2, X3, and X4 each independently means a single bond, C1-6 alkylene, etc.; A2 means optionally substituted phenyl, etc.; A1 means an optionally substituted group represented by -C(=Q1)- &lsqb ...


8
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu, Negi Shigeto, Naito Toshihiko: Fused imidazole compounds and remedies for diabetes mellitus. Eisai R&Amp Amp D Management, February 27, 2002: KR1020017016643

Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R1 is optionally alkyla ...