1
Milstein Sam J, Barantsevitch Evgueni: Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof. Emisphere Technologies, Milstein Sam J, Barantsevitch Evgueni, ROBINSON Joseph R, October 27, 1994: WO/1994/023702 (5 worldwide citation)

Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. Figure 1 illustrates levels of glucose detected in rat serum taken from rats orally administered microsphere encapsulated insulin or raw (une ...


2
Leone Bay Andrea, Ho Koc Kan, Sarubbi Donald J, Milstein Sam J, Press Jeffery Bruce: Composes et compositions servant a lapport dagents actifs, Compounds and compositions for delivering active agents. Emisphere Technologies, Emisphere Technologies, ROBIC, October 3, 1996: CA2214323 (3 worldwide citation)

Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcu-taneous, sublingual, and intranasal administra-tion, are provided, and methods of preparation of the modified amino acid ...


3
Milstein Sam J, Barantsevitch Evgueni N Apartm, Sarubbi Donald J, Leone Bay Andrea, Paton Duncan R: Oral drug delivery compositions and methods. Emisphere Tech, February 14, 1996: EP0696208-A1 (1 worldwide citation)

The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with activ ...


4
Leone Bay Andrea, Ho Koc Kan, Leipold Harry R, Milstein Sam J, Sarubbi Donald J, Wang Eric, David Gushunaidaa: Composition for delivering compound and activator. Emisphere Technolgies, May 15, 2001: JP2001-131090 (1 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a carrier compound and a composition effective for delivering an activator and to provide an administration method including an oral administration and a preparation method. SOLUTION: This composition contains (A) at least one activator and (B) a compound of the formu ...


5
Kantor Martin L, Barantsevitch Evgueni, Milstein Sam J: Microencapsulated fragrances and method for preparation. Emisphere Technologies, Kantor Martin L, Barantsevitch Evgueni, Milstein Sam J, ROBINSON Joseph R, December 18, 1997: WO/1997/047288 (1 worldwide citation)

This invention provides an encapsulated fragrance in which the fragrance is controlled can be released by exposing the encapsulated fragrance to a solution of a predetermined pH. The invention also contemplates a process for preparing encapsulated fragrances.


6
Leone Bay Andrea, Ho Koc Kan, Sarubbi Donald J, Milstein Sam J, Press Jeffery Bruce: Compounds and compositions for delivering active agents. Emisphere Technologies, Leone Bay Andrea, Ho Koc Kan, Sarubbi Donald J, Milstein Sam J, Press Jeffery Bruce, sROBINSON Joseph R, October 3, 1996: WO/1996/030036 (1 worldwide citation)

Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid c ...


7
Leone Bay Andrea, Ho Koc Kan, Sarubbi Donald J, Milstein Sam J, Press Jeffery Bruce: Compounds and compositions for delivering active agents. Emisphere Tech, January 14, 1998: EP0817643-A1

Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at le ...


8
Milstein Sam J, Barantsevitch Evgueni N: Oral delivery system for desferrioxamine, insulin and cromolyn sodium. Emisphere Tech, January 31, 2001: EP1072255-A2

Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfon ...


9
Milstein Sam J, Barantsevitch Eugene N, Wang Nai Fang, Liao Jun, Smart John E, Conticello Richard D, Ottenbrite Raphael M: Polymeric delivery agents and delivery agent compounds. Emisphere Tech, Univ Virginia Commonwealth, October 24, 2001: EP1146860-A2

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.


10
Milstein Sam J, Barantsevitch Evgueni N: Desferrioxamine oral delivery system. Emisphere Tech, August 21, 1996: EP0726771-A1

Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfon ...