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Harmon Hoffman Jr, Kemal Schankereli, Milos Chvapil: Drug delivery collagen-impregnated synthetic vascular graft. Meadox Medicals, Blum Kaplan, March 30, 1993: US05197977 (348 worldwide citation)

A collagen impregnated vascular graft including drug materials complexed with the collagen to be released slowly from the graft following implant. The graft is a porous synthetic vascular graft substrate having collagen fixed to the graft substrate and cross-linking the collagen in situ to render th ...


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Milos Chvapil: Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers. Bio Products, Cahill Sutton & Thomas, January 7, 1992: US05078744 (140 worldwide citation)

A method of repairing connective tissue uses a heterograft for supporting ingrowth of ligament or tendon connective tissue to replace damaged connective tissue in a subject which is composed of a plurality of long, thin fibers extracted from animal connective tissue having generally the same mechani ...


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Vladimir A Stoy, Milos Chvapil: Injectable physiologically-acceptable polymeric composition. S K Y Polymers, December 23, 1986: US04631188 (124 worldwide citation)

There is disclosed a non-toxic physiologically-acceptable polymeric composition comprised of water insoluble, non-crosslinked polymeric compounds having a solubility parameter of between 9.2 and 15.5 (cal/cc).sup.1/2 dissolved in a polar, non-toxic water miscible solvent, which polymeric composition ...


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Milos Chvapil: Use of transparent membranes made of hydrogel polymers as a cover for various organs during surgery. Malliner Laboratories, Cahill Sutton & Thomas, October 18, 1988: US04777943 (115 worldwide citation)

The object of this invention is to use a variety of thin membranes, 1.0 to 2.0 mm thick made of any hydrogel polymer, as a temporary cover on organs exposed to air during surgery. The membranes are characterized by a high water content in excess of 85 weight percent, unique biocompatibility, transpa ...


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Milos Chvapil, Bruce Barber: Method of treating a wound. Bruce Barber, Richard P Crowley, July 13, 1993: US05227168 (61 worldwide citation)

An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite ...


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Milos Chvapil: Method for making collagen sponge. Medi Coll, Cahill Sutton & Thomas, March 18, 1980: US04193813 (41 worldwide citation)

Method for making a collagen sponge including the following steps. Native collagen form of fibrillar protein is comminuted and homogenized in an acid environment; noncollagenous material is removed and residual collagen is mixed with water the pH of the resulting slurry is adjusted to 4.5 to 5.0 by ...


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Milos Chvapil, Bruce Barber: Method of preparing an antimicrobial wound dressing. Bruce A Barber, Richard P Crowley, April 14, 1992: US05104660 (31 worldwide citation)

An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite ...


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Milos Chvapil, Bruce A Barber: Antimicrobial wound dressing. Bruce A Barber, Richard P Crowley, May 26, 1992: US05116620 (30 worldwide citation)

An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite ...


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Milos Chvapil: Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs. Bio Products, November 27, 1984: US04485088 (29 worldwide citation)

The disclosure deals with a method of treating fibrotic lesions related to abnormal collagen polymerization by topical administration of lathyrogenic substances, such as .beta.-aminopropionitrile fumarate, aminoacetonitrile, D-penicillamine, into the site of the injury. The lathyrogenic drugs are ad ...