1
Miesenbock Gero A, Zemelman Boris V: Heterologous stimulus-gated ion channels and methods of using same. Sloan Kettering Institute For Cancer Research, Miesenbock Gero A, Zemelman Boris V, LARSON Marina T, December 11, 2003: WO/2003/102156 (10 worldwide citation)

Methods and compositions to activate a genetically designated target cell (or population of targetcells) artificially, in vivo or in vitro, employ triggering of heterologous stimulus-gated ion channels to activate the cells. The stimulus-gated ion channels are suitably TRPV1, TRPM8 or P2X2. A stimul ...


2
Miesenbock Gero, Zemelman Boris: Bio-synthetic photostimulators and methods of use. Sloan Kettering Institute For Cancer Research, ADLER Benjamin A, February 27, 2003: WO/2003/016486 (8 worldwide citation)

Method for rendering a cell sensitive to stimulation. In a preferred embodiment, the method comprises introducing, into a cell, nucleic acid sequences encoding at least an opsin gene product, an arrestin gene product, and the alpha subunit of the heterotrimeric G protein of the G¿q? family. The intr ...


3
Miesenbock Gero, Rothman James E, de, Angelis Dino A: Hybrid molecules for optically detecting changes in cellular microenvironments. Memorial Sloan Kettering Cancer Center, Miesenbock Gero, Rothman James E, de, Angelis Dino A, SONNENFELD Kenneth H, August 20, 1998: WO/1998/036081 (1 worldwide citation)

The invention relates to methods and compositions which utilize the emission of light to monitor changes in microenvironments involving cells. The invention is especially useful for monitoring exocytotic activity such as detecting quantal release of synaptic vesicles. Fusion proteins of $i(Cypridina ...


4
Miesenbock Gero A, Zemelman Boris V: Heterologous stimulus-gated ion channels and methods of using same. Sloan Kettering Institutefor C, May 25, 2005: EP1532452-A2

Methods and compositions to activate a genetically designated target cell (or population of targetcells) artificially, in vivo or in vitro, employ triggering of heterologous stimulus-gated ion channels to activate the cells. The stimulus-gated ion channels are suitably TRPV1, TRPM8 or P2X2. A stimul ...


5
Miesenbock Gero, de Angelis Dino A, Rothman James E: Ph sensitive mutants of gfp for optically detecting changes in cellular microenvironments. Sloan Kettering Inst Cancer, July 20, 2005: EP1555323-A2

The invention relates to methods and compositions which utilize the emission of light to monitor changes in microenvironments involving cells. The invention is especially useful for monitoring exocytotic activity such as detecting quantal release of synaptic vesicles. Fusion proteins of Cypridina lu ...


6
Miesenbock Gero, Rothman James E, de Angelis Dino A: Hybrid molecules for optically detecting changes in cellular microenvironments. Sloan Kettering Inst Cancer, March 1, 2000: EP0981633-A2

The invention relates to methods and compositions which utilize the emission of light to monitor changes in microenvironments involving cells. The invention is especially useful for monitoring exocytotic activity such as detecting quantal release of synaptic vesicles. Fusion proteins of Cypridina lu ...


7
Miesenbock Gero A, Zemelman Boris V: Heterologous stimulus-gated ion channels and methods of using same. Sloan Kettering Inst Cancer, wang jingchao, September 21, 2005: CN03817754

Methods and compositions to activate a genetically designated target cell (or population of targetcells) artificially, in vivo or in vitro, employ triggering of heterologous stimulus-gated ion channels to activate the cells. The stimulus-gated ion channels are suitably TRPV1, TRPM8 or P2X2. A stimul ...