1
Michel Schneider: Process for the preparation of liposomes in aqueous solution. Battelle Memorial Institute, Finnegan Henderson Farabow Garrett & Dunner, September 23, 1980: US04224179 (239 worldwide citation)

A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipop ...


2
Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl Sutherland: Stable microbubbles suspensions injectable into living organisms. Bracco International, Nixon & Vanderhye, January 10, 1995: US05380519 (202 worldwide citation)

Gas or air filled microbubble suspensions in aqueous phase usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing ...


3
Michel Schneider, Bernard Lamy: Process for the dehydration of a colloidal dispersion of lipsomes. Battelle Memorial Institute, Finnegan Henderson Farabow Garrett & Dunner, October 21, 1980: US04229360 (165 worldwide citation)

The invention concerns a process for the dehydration of a colloidal dispersion of liposomes in an aqueous liquid medium, this process being aimed at extending the conservation of the liposomes and to enable their efficient use at a later date.


4
Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl Sutherland: Stable microbubbles suspensions injectable into living organisms. Sintetica, Nixon & Vanderhye, December 21, 1993: US05271928 (164 worldwide citation)

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing ...


5
Feng Yan, Michel Schneider, Jean Brochot: Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method. Bracco Research, Nixon & Vanderhye, September 17, 1996: US05556610 (154 worldwide citation)

The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers pro ...


6
Michel Schneider, Feng Yan, Pascal Grenier deceased, Jerome Puginier, Marie Bernadette Barrau: Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof. Bracco International, Nixon & Vanderhye, May 9, 1995: US05413774 (137 worldwide citation)

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of ...


7
Michel Schneider: Process for the preparation of liposomes. Battelle Memorial Institute, Robert E Burns, Emmanuel J Lobato, Bruce L Adams, May 16, 1978: US04089801 (135 worldwide citation)

Synthetic liposomes, for example containing a biologically active substance, are prepared by dispersing a first aqueous liquid with the aid of ultrasonic vibration in a water-immiscible carrier liquid less dense than water in the presence of a compound of the formula XY where X is a hydrophilic pola ...


8
Daniel Bichon, Philippe Bussat, Michel Schneider: Method of making polymeric gas or air filled microballoons for ultrasonic echography. Bracco International, Nixon & Vanderhye, January 27, 1998: US05711933 (100 worldwide citation)

Method of making gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient for use in ultrasonic contrast compositions are described.


9
Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan: Stable microbubble suspensions as enhancement agents for ultrasound echography. Bracco International, Nixon & Vanderhye, August 29, 1995: US05445813 (99 worldwide citation)

Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse ...


10
Michel Schneider: Reversibly precipitable immobilized enzyme complex and a method for its use. Battelle Memorial Institute, Robert E Burns, Emmanuel J Lobato, Bruce L Adams, May 9, 1978: US04088538 (95 worldwide citation)

A process for using and preparing a reversibly soluble enzymatically active polymer enzyme product which consists of an enzyme covalently bonded to a water soluble organic polymer selected from polyacrylic acid, dextran, carboxy methyl cellulose, and polyethylene glycol which have carboxyl or amino ...