1
Michel G M Perbost: Methods of making polymeric arrays. Agilent Technologies, Gordon Stewart, January 9, 2001: US06171797 (79 worldwide citation)

Methods are provided for making arrays of distinct polymers covalently bonded to the surface of the a solid support. In the subject methods, at least two distinct polymers, e.g. nucleic acids, are contacted with the surface of a solid support under conditions sufficient for the nucleic acids to beco ...


2
Arthur Schleifer, Michael P Caren, Leslie A Leonard, Charles Z Hotz, Michel G M Perbost: Method and apparatus for fabricating replicate arrays of nucleic acid molecules. Agilent Technologies, October 30, 2001: US06309828 (59 worldwide citation)

A method and apparatus for fabricating replicate arrays of nucleic acid molecules include the preparation of the molecules and the application the molecules onto a substrate in an ordered array. The apparatus comprises a synthesis unit and a plurality of outlets. The synthesis unit comprises a plura ...


3
Michel G M Perbost: Biopolymer arrays and their fabrication. Agilent Technologies, Gordon Stewart, October 23, 2001: US06306599 (23 worldwide citation)

A method of fabricating an addressable array of biopolymers on a substrate using a biomonomer with a first linking group which must be activated for linking to a substrate bound moiety, and apparatus and computer program products for executing the method. The method includes forming on a region of t ...


4
Jonathan P Earhart, Michel G M Perbost: Method for synthesizing a specific, surface-bound polymer uniformly over an element of a molecular array. Agilent Technologies, October 9, 2001: US06300137 (18 worldwide citation)

A method for specifically and uniformly synthesizing desired polymers within molecular array elements. Droplets containing a reactive monomer are successively applied to the elements of a molecular array in order to synthesize a substrate-bound polymer. Application of an initial droplet, having a fi ...


5
Michel G M Perbost, Steven M Lefkowitz, Roy H Kanemoto, Carol T Schembri: Chemical arrays. Agilent Technologies, November 27, 2007: US07300798 (17 worldwide citation)

A method and apparatus for using arrays of polymers each having a pattern of features over a corresponding array region on a surface of a flexible elongated web. In this method each array region may be exposed to a corresponding continuous volume of a sample fluid. A method and apparatus are also pr ...


6
Steven M Lefkowitz, Michel G M Perbost, Roy H Kanemoto, Carol T Schembri: Chemical arrays. Agilent Technologies, Gordon Steward, January 11, 2005: US06841663 (17 worldwide citation)

Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a ...


7
Joel Myerson, Michel G M Perbost, Douglas J Dellinger, Geraldine F Dellinger: Method of synthesizing polynucleotides using ionic liquids. Agilent Technologies, August 12, 2008: US07411061 (15 worldwide citation)

A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive group may be on a second nucleotide, a polynucleotide, or on a moiety on an insoluble substrate, for examp ...


8
Joel Myerson, Michel G M Perbost, Douglas J Dellinger, Geraldine F Dellinger: Use of ionic liquids for fabrication of polynucleotide arrays. Agilent Technologies, October 14, 2008: US07435810 (14 worldwide citation)

A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of ...


9
Joel Myerson, Michel G M Perbost, Douglas J Dellinger, Geraldine F Dellinger: Use of ionic liquids for fabrication of polynucleotide arrays. Agilent Technologies, Michael J Beck, February 8, 2005: US06852850 (13 worldwide citation)

A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of ...


10
Michel G M Perbost, Steven M Lefkowitz: Method of shielding biosynthesis reactions from the ambient environment on an array. Agilent Technologies, May 14, 2002: US06387636 (11 worldwide citation)

A method of fabricating an array of biopolymers provides a shield for biochemical reactions and biochemical reactants and is particularly useful for those reactions and reactants that are susceptible to reaction with a component of the ambient environment during the fabrication of the array. The met ...