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Dai Yujia, Davidsen Steven K, Ericsson Anna M, Hartandi Kresna, Ji Zhiqin, Michaelides Michael R: Indazole, benzisoxazole, and benzisothiazole kinase inhibitors. Abbott Laboratories, Dai Yujia, Davidsen Steven K, Ericsson Anna M, Hartandi Kresna, Ji Zhiqin, Michaelides Michael R, STEELE Gregory, December 29, 2004: WO/2004/113304 (37 worldwide citation)

Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.


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Michaelides Michael R, Ji Zhiqin: Inhibitors of protein kinases. Abbott Laboratories, Michaelides Michael R, Ji Zhiqin, DONNER B Gregoryet al, November 12, 2009: WO/2009/136966 (5 worldwide citation)

Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. One embodiment of this invention, therefore, pertains to compounds that inhibit Aurora-kinases, the compounds having formula I and therapeutically acceptab ...


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Michaelides Michael R, Zhiqin Ji: Condensed heterocyclic compounds as inhibitors of protein kinases. Abbott Laboratories, Michaelides Michael R, Zhiqin Ji, DONNER Gregory B, November 20, 2008: WO/2008/141145 (2 worldwide citation)

Compounds having Formula (I) that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.


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Dai Yujia, Zhiqin Ji, Michaelides Michael R: Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases. Abbott Laboratories, Dai Yujia, Zhiqin Ji, Michaelides Michael R, DONNER B Gregory, January 22, 2009: WO/2009/012312 (2 worldwide citation)

Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.


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Hirst Gavin C, Arnold Lee D, Burchat Andrew, Wishart Neil, Calderwood David, Wada Carol K, Michaelides Michael R, Ji Zhiqin, Muckey Melanie: Kinase inhibitors. Abbott Laboratories, Hirst Gavin C, Arnold Lee D, Burchat Andrew, Wishart Neil, Calderwood David, Wada Carol K, Michaelides Michael R, Ji Zhiqin, Muckey Melanie, O BRIEN Gayle B, October 2, 2003: WO/2003/080064 (2 worldwide citation)

The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.


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Davidsen Steven K, Florjancic Alan Scott, Sheppard George S, Giesler Jamie R, Xu Lianhong, Guo Yan, Curtin Michael L, Michaelides Michael R, Wada Carol K, Holms James H: C-terminal ketone hydroxamic acid inhibitors of matrix metalloproteinases and tnfa secretion. Abbott Lab, December 22, 1999: EP0964851-A1 (1 worldwide citation)

C-terminal compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in ...