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Michael Schriewer, Klaus Grohe, Hans Joachim Zeiler, Karl G Metzger: Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, November 10, 1987: US04705788 (29 worldwide citation)

Novel antibacterially active 7-amino-1-(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the formula ##STR1## in which X.sup.1 and X.sup.2 can be identical or different and represent hydrogen or halogen,


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Michael Schriewer, Klaus Grohe, Uwe Petersen, Ingo Haller, Karl G Metzger, Rainer Endermann, Hans Joachim Zeiler: Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, March 13, 1990: US04908366 (27 worldwide citation)

Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,


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Michael Schriewer, Klaus Grohe, Uwe Petersen: Quinolone- and 1,8-naphthyridin-4-one-carboxylic acids which are C-bonded in the 7-position. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, September 11, 1990: US04956465 (20 worldwide citation)

As novel intermediates for antibacterials, the quinolone- and 1,8-naphthyridine-4-one-carboxylic acids which are C-bonded in the 7-position of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.3, or an acid amide group --CONR.sup.4 R.sup.5, where ...


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Klaus Grohe, Michael Schriewer: Antibacterial 1,8-bridged 4-quinolone-3-carboxylic acids. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, August 9, 1988: US04762831 (20 worldwide citation)

A process for the preparation of a 1,8-bridged 4-quinolone-3-carboxylic acid of the formula ##STR1## wherein the substituents are defined hereinbelow. Some of the compound are new. The old and new compounds are antibacterials and promote animal growth.


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Stephan Bartel, Andreas Krebs, Franz Kunisch, Uwe Petersen, Thomas Schenke, Klaus Grohe, Michael Schriewer, Klaus Dieter Bremm, Rainer Endermann, Karl Georg Metzger: Quinolone- and naphthyridonecarboxylic acid derivatives. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, October 10, 1995: US05457104 (14 worldwide citation)

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and feed additives containing them.


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Michael Schriewer, Klaus Grohe, Hans Joachim Zeiler, Karl G Metzger: 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, February 16, 1988: US04725595 (14 worldwide citation)

Antibacterially active new 1,8-bridged 4-quinolone-3-carboxylic acid derivatives of the formula ##STR1## in which Y is carboxyl or a derivative thereof