1
Wayne R Gombotz, Michael S Healy, Larry R Brown: Very low temperature casting of controlled release microspheres. Enzytech, Kilpatrick & Cody, May 28, 1991: US05019400 (302 worldwide citation)

A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolve ...


2
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, July 13, 1999: US05922253 (64 worldwide citation)

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, whereby the microdroplets freeze ...


3
Wayne R Gombotz, Michael S Healy, Larry R Brown, Henry E Auer: Process for producing small particles of biologically active molecules. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, May 27, 2003: US06569458 (64 worldwide citation)

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are ly ...


4
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, November 28, 2000: US06153129 (16 worldwide citation)

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...


5
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, March 19, 2002: US06358443 (7 worldwide citation)

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...


6
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, April 27, 2004: US06726860 (1 worldwide citation)

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...


7
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, May 2, 2006: US07037450

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...


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Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, cheng wei, June 10, 1998: CN96193910

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...


10
Paul F Herbert, Michael S Healy: Production scale method of forming microparticles. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds PC, December 16, 2004: US20040253316-A1

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur ...