1
Carter Kittrell, Robert M Cothren Jr, Michael S Feld: Spectral diagonostic and treatment system. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, April 19, 1994: US05304173 (283 worldwide citation)

A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at th ...


2
Carter Kittrell, Robert M Cothren, Michael S Feld, Joseph J Baraga, Kyungwon An, Rebecca Richards Kortum, Richard P Rava, Young D Park, Anand V Mehta, Paola Taroni, Lucene Tong, Ramachandra R Dasari: Method for laser induced fluorescence of tissue. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, October 8, 1996: US05562100 (269 worldwide citation)

A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed thro ...


3
Carter Kittrell, Robert L Willett, Cynthia de los Santos Pacheco, Leo T Kenny, Michael S Feld: Visible fluorescence spectral diagnostic for laser angiosurgery. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, January 12, 1988: US04718417 (245 worldwide citation)

A method of diagnosis of the type of tissue in an artery, including distinguishing artery wall from atheromateous plaque is described, in which a catheter with one or more optical fibers is enclosed at a distal end by an optical shield transparent to light radiation and wherein the proximal end of t ...


4
Carter Kittrell, Robert M Cothren Jr, Michael S Feld: Catheter for laser angiosurgery. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, December 2, 1997: US05693043 (241 worldwide citation)

A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at th ...


5
Carter Kittrell, Robert M Cothren Jr, Michael S Feld: Laser endoscope for spectroscopic imaging. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, June 7, 1994: US05318024 (238 worldwide citation)

A laser endoscope is disclosed for generating a spectrally resolved spatial image of tissue. Fiber optics positioned within an optically shielded endoscope are used to deliver laser radiation to tissue to be imaged. Radiation returning through the fiber optics from the tissue is spectrally resolved ...


6
Carter Kittrell, Robert M Cothren, Michael S Feld, Joseph J Baraga, Kyungwon An, Rebecca Richards Kortum, Richard P Rava, Young D Park, Anand Mehta, Paola Taroni, Lucene Tong, Ramachandra R Dasari: Method for laser induced fluorescence of tissue. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, May 30, 1995: US05419323 (212 worldwide citation)

A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed thro ...


7
Jun Wu, Michael S Feld, Richard P Rava, Firooz Partovi: Calibrated spectrographic imaging. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, September 26, 1995: US05452723 (178 worldwide citation)

The present application is directed to the use of photon migration analysis to provide a method of analyzing the diffuse reflectance, fluorescence, Raman or other types of spectra obtained from tissue. This procedure provides a means for processing spectral data such that the distortion in fluoresce ...


8
Lev T Perelman, Vadim Backman, Michael S Feld, George Zonios, Irving Itzkan, Ramasamy Manoharan: Measuring tissue morphology. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, July 18, 2000: US06091984 (172 worldwide citation)

The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the cha ...


9
Carter Kittrell, Gary B Hayes, Michael S Feld: Method for making optical shield for a laser catheter. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, March 10, 1987: US04648892 (165 worldwide citation)

A method of forming an optical shield for a laser catheter is disclosed in which a rod of light transmissive material is optically polished and inserted into a tube of similar material and fused and the distal end of the rod is cut and the assembly is optically polished at the distal end.


10
Rebecca Richards Kortum, Lucene Tong, Michael S Feld: Spectral diagnosis of diseased tissue. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, June 6, 1995: US05421337 (165 worldwide citation)

The present invention relates to a method and apparatus for diagnosing the condition of gastrointestinal tissue. The method and apparatus excite fluorophores within a portion of gastrointestinal tissue with a laser to cause the fluorophores to emit fluorescent radiation. The presence of abnormal tis ...