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Matthew Lee Brown, Mui Cheung, Scott Howard Dickerson, Cassandra Gauthier, Philip Anthony Harris, Robert Neil Hunter, Gregory Pacofsky, Michael Robert Peel, Jeffrey Alan Stafford: 1,3-Oxazole compounds for the treatment of cancer. SmithKline Beecham Corporation, John L Lemanowicz, Jennifer L Fox, March 13, 2007: US07189712 (7 worldwide citation)

Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


3
Michael John Alberti, Ian Robert Baldwin, Mui Cheung, Stuart Cockerill, Stephen Flack, Philip Anthony Harris, David Kendall Jung, Gregory Peckham, Michael Robert Peel, Jennifer Gabriel Badiang, Kirk Stevens, James Marvin Veal: Fused pyrazole derivatives being protein kinase inhibitors. Glaxo Group, Lorie Ann Morgan, January 23, 2007: US07166597 (6 worldwide citation)

Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors


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Philip Anthony Harris, Robert N Hunter, Robert Walton McNutt Jr, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Robert Peel, Edgar Raymond Wood III: Oxindole derivatives. SmithKline Beecham Corporation, John L Lemanowicz, November 15, 2005: US06964977 (4 worldwide citation)

The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signa ...


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Jeffrey Mark Besterman, Michael Glenn Evans, Karen Elizabeth Lackey, Michael Joseph Luzzio, Michael Robert Peel, Daniel David Sternbach: Water soluble camptothecin derivatives. Glaxo Wellcome, John L Lemanowicz, August 8, 2000: US06100273 (3 worldwide citation)

The present invention relates to water soluble, camptothecin derivatives of formula (I). ##STR1## wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): ##STR2## X is selected from the group consisting of alkyl, aryl, (CH.sub.2).sub.m OR.sup.1, (CH.sub.2).sub.m SR.sup.1 and (CH.sub.2).s ...


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Jennifer G Badiang, Scott Howard Dickerson, Philip Anthony Harris, David Kendall Jung, Michael Robert Peel, Michael John Reno, Tara Renae Rheault, Kirk Lawrence Stevens, Francis Xavier Tavares, James Marvin Veal: Pyrazolopyridazine derivatives. SmithKline Beecham Corporation, John L Lemanowicz, Kathryn L Coulter, October 9, 2007: US07279473 (2 worldwide citation)

Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases.


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Keqiang Li, David Renwick Houck, Cyprian Okwara Ogbu, Michael Robert Peel, Andrew William Scribner: Macrocycles. Scynexis, Jones Day, September 17, 2013: US08536114 (1 worldwide citation)

Disclosed herein are compounds of general formula (I): wherein A, B, R1 and R2 are as defined in the specification, and their use as pharmaceuticals.


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Michael John Alberti, Stanley D Chamberlain, Mui Cheung, Kristjan Gudmundsson, Philip Anthony Harris, Brian A Johns, David Kendall Jung, Michael Robert Peel, Jennifer Badiang Stanford: Pyrazolopyridines, process for their preparation and use as therapeutic compounds. SmithKline Beecham Corporation, Lorie Ann Morgan, September 19, 2006: US07109209 (1 worldwide citation)

The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.


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Michael John Alberti, Stanley D Chamberlain, Mui Cheung, Kristjan Gudmundsson, Philip Anthony Harris, Brian A Johns, David Kendall Jung, Michael Robert Peel, Jennifer Badiang Stanford: Pyralopyridines, process for their preparation and use as therapeutic compounds. SmithKline Beecham Corporation, Lorie Ann Morgan, April 25, 2006: US07034030 (1 worldwide citation)

The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.


10
Keqiang Li, Ahmed Mamai, Michael Robert Peel: Macrocyclic peptides. Scynexis, Jones Day, July 28, 2015: US09090671

Disclosed are cyclosporine derivatives in which the 3-Sarcosine carbon and 5-Valine nitrogen are each substituted by a non-hydrogen substituent, and their use as pharmaceuticals, in particular for the treatment of hepatitis C virus.