1
Ni Ding, Michael N Helmus: Drug release stent coating process. Schneider, Pennie & Edmonds, November 17, 1998: US05837313 (777 worldwide citation)

A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologi ...


2
Ni Ding, Michael N Helmus: Drug coating with topcoat. Schneider, Pennie & Edmonds, August 8, 2000: US06099562 (693 worldwide citation)

A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than t ...


3
Ni Ding, Michael N Helmus: Medical devices with long term non-thrombogenic coatings. Schneider, September 19, 2000: US06120536 (690 worldwide citation)

A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of biologically active material, particularly heparin, dispersed in the coating in combination with a non-thr ...


4
Michael N Helmus, M Joshua Tolkoff, Carol L Raleigh: Medical device polymer. Harbor Medical Devices, Fish & Richardson, September 5, 1995: US05447724 (466 worldwide citation)

A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeri ...


5
Ni Ding, Michael N Helmus: Drug release stent coating. Boston Scientific Corporation, March 19, 2002: US06358556 (461 worldwide citation)

A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologi ...


6
Fritz Hostettler, David Rhum, Michael R Forman, Michael N Helmus, Ni Ding: Medical device coated with interpenetrating network of hydrogel polymers. Schneider, Vidas Arrett & Steinkraus, September 19, 2000: US06120904 (453 worldwide citation)

A medical device comprising an organic polymer substrate material having a coating thereon, the coating comprising an interpenetrating network of two different hydrogel polymers, one of which is a polyurethane/polyurea hydrogel polymer, the polyurethane/polyurea hydrogel polymer being linked to the ...


7
Fritz Hostettler, David Rhum, Michael R Forman, Michael N Helmus, Ni Ding: Process for preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coating, coated polymer and metal substrate materials, and coated medical devices. Schneider, Vidas Arrett & Steinkraus, June 27, 2000: US06080488 (378 worldwide citation)

A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenacio ...


8
Michael N Helmus, M Joshua Tolkoff, Carol L Raleigh: Medical device polymer. Harbor Medical Devices, Fish & Richardson P C, October 29, 1996: US05569463 (367 worldwide citation)

A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeri ...


9
Ni Ding, Michael N Helmus: Drug coating with topcoat. Schneider, September 4, 2001: US06284305 (296 worldwide citation)

A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than t ...


10
Michael N Helmus, Michael R Forman: Drug delivery guidewire. Schneider, Peter C Richardson, Lawrence C Akers, Philip C Strassburger, October 29, 1996: US05569197 (226 worldwide citation)

This invention relates to a drug delivery device having a hollow tube which is configured to serve as a guide wire for intraluminal procedures. The distal portion of the tube has at least one opening which has a diameter suitable for the infusion of a drug formulation therethrough. The tube is prefe ...