1
Tarran Jones
Robert W Chestnut, Margaret J Polley, James C Paulson, S Tarran Jones, Jose W Saldanha, Mary M Bendig, Michael Kriegler, Carl Perez, Robert Bayer, Michael Nunn: Antibodies to P-selectin and their uses. Cytel Corporation, Campbell & Flores, September 1, 1998: US05800815 (24 worldwide citation)

The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes to activated platelets and/or to activated vascular endothelium in vivo. Both murine and humanized anti ...


2
Tarran Jones
Robert W Chesnut, Margaret J Polley, James C Paulson, S Tarran Jones, Jose W Saldanha, Mary M Bendig, Michael Kriegler, Carl Perez, Robert Bayer, Michael Nunn: Method for detecting the presence of P-selectin. Cytel Corporation, Campbell & Flores, March 7, 2000: US06033667 (4 worldwide citation)

The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes to activated platelets and/or to activated vascular endothelium in vivo. Both murine and humanized anti ...


3
Michael Kriegler, Francis P McCormick: Retroviral vectors expressing cytokines. Chiron Corporation, Norman J Kruse, Donald J Pochopien, Robert P Blackburn, June 3, 1997: US05635399 (53 worldwide citation)

A drug delivery virion which contains an expression system for the desired protein active ingredient packaged in an envelope derived from a retrovirus is especially useful in administering materials which need to cross cell membranes in order to serve their function.


4
Michael Kriegler, Carl Perez: Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions. Cetus Oncology Corporation, Lewis S Gruber, Kenneth M Goldman, Robert P Blackburn, June 28, 1994: US05324655 (22 worldwide citation)

A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes ...


5
Michael Kriegler, Carl Perez, Robert F Halenbeck, David A Jewell, Kirston E Koths: Compositions for the inhibition of TNF hormone formation and uses thereof. Chiron Corporation, Kimberlin L Morley, Robert P Blackburn, McAndrews Held & Malloy, December 7, 1999: US05998378 (16 worldwide citation)

Compounds having proteolytic inhibitory activity useful for treating diseases, particularly as applied to the treatment of sepsis, AIDS or autoimmune diseases, resulting from a decrease in the circulating level of mature protein hormones derived from the proteolytic cleavage of prohormone precursors ...


6
Michael Kriegler, Carl F Perez: Recombinant host cells encoding TNF proteins. Chiron Corporation, Donald Pochopien, Norman J Kruse, Robert P Blackburn, March 30, 1999: US05888814 (13 worldwide citation)

A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes ...


7
Michael Kriegler, Carl F Perez: TNF deletion muteins. Chiron Corporation, Donald Pochopien, Norman J Kruse, Robert P Blackburn, March 30, 1999: US05889156 (9 worldwide citation)

A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes ...


8
Michael Kriegler, Danute E Nitecki: Methods for the identification of cytokine convertase inhibitors. Cetus Oncology Corporation, Donald J Pochopien, Paul B Savereide, Robert P Blackburn, June 6, 1995: US05422425 (8 worldwide citation)

Compositions and methods are described for identifying inhibitors of mature protein hormone formation from a prohormone, and prophylactic and therapeutic uses of the inhibitors for treating diseases associated with elevated levels of the mature hormones, particulary sepsis, and autoimmune diseases.


9
Michael Kriegler, Carl F Perez: Human til cells expressing recombinant TNF prohormone. Chiron Corporation, Donald Pochopien, Norman J Kruse, Robert P Blackburn, February 23, 1999: US05874077 (6 worldwide citation)

Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF .gamma. sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormon ...


10
Michael Kriegler, Carl F Perez: Infective protein delivery system. Chiron Corporation, Donald Pochopien, Norman J Kruse, Robert P Blackburn, December 15, 1998: US05849586 (6 worldwide citation)

A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes ...