1
Stephen Thomas Davis, Scott Howard Dickerson, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, April 9, 2002: US06369086 (39 worldwide citation)

The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In p ...


2
Stephen Thomas Davis, Scott Howard Dickerson, Stephen Vernon Frye, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxindole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors and compositions and methods of treating chemotherapy and radiation therapy side effects. SmithKline Beecham Corporation, Jennifer L Fox, September 12, 2006: US07105529 (34 worldwide citation)

Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 aliphatic, C1-6 aliphatic-amino, R7-sulfonyl, R7 sulfonyl-C1-12 aliphatic, R7-aminosulfonyl, R7-aminosulfonyl-C1-12 alipha ...


3
John Charles Kath, Michael Joseph Luzzio: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer, Steve Zelson, Pamela C Ancona, September 19, 2006: US07109337 (14 worldwide citation)

The present invention relates to a compound of the formula 1 wherein R1–R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abn ...


4
John Charles Kath, Michael Joseph Luzzio: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer, Steve Zelson, Pamela C Ancona, September 19, 2006: US07109335 (13 worldwide citation)

The present invention relates to a compound of the formula 1 wherein R1–R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abn ...


5
John Charles Kath, Michael Joseph Luzzio: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer, Steve Zelson, David L Kershner, June 26, 2007: US07235562 (12 worldwide citation)

The present invention relates to a compound of the formula 1 wherein R1-R4 and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment ...


6
John Charles Kath, Michael Joseph Luzzio: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer, David L Kershner, Suzanne M Bates, Bryan C Zielinski, April 1, 2008: US07351712 (11 worldwide citation)

The present invention relates to a compound of the formula 1 wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abn ...


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Michael Joseph Luzzio, Bingwei Vera Yang, Matthew Arnold Marx: Thiophene derivatives useful as anticancer agents. Pfizer, Steve T Zelson, Garth Butterfield, November 15, 2005: US06964961 (11 worldwide citation)

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R1, R2 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 ...


9
Michael Joseph Luzzio, Kevin Daniel Freeman Cook, Samit Kumar Bhattacharya, Matthew Merrill Hayward, Catherine Angela Hulford, Christopher Lowell Autry, Xumiao Zhao, Jun Xiao, Kendra Louise Nelson: Sulfonyl amide derivatives for the treatment of abnormal cell growth. Pfizer, Jeffrey H Tidwell, Stephen D Prodnuk, Leslie A Robinson, April 19, 2011: US07928109 (10 worldwide citation)

The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds i ...


10
John Charles Kath, Michael Joseph Luzzio: Pyrimidine derivatives for the treatment of abnormal cell growth. Pfizer, Steve Zelson, David L Kershner, December 5, 2006: US07145008 (9 worldwide citation)

The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein R1–R4 and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Thi ...