1
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, November 9, 2010: US07829556 (38 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


2
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, James T Olesen, Jeffrey A Sutton, August 21, 2012: US08247565

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


3
Michael Jirousek, Ho Peng Koh, Gottfried Hack, Friedrich Rastelli: Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. Koninklijke Philips Electronics, Michael E Belk, April 29, 2008: US07367033

Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier ( ...


4
Michael Jirousek, Ho Peng Koh, Gottfried Hack, Friedrich Rastelli: Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. Philips Intellectual Property & Standards, August 17, 2006: US20060184952-A1

Device for scanning a disc-shaped data carrier, comprising a transport system for transporting the data carrier. In the case of a device (1) for scanning a disc-shaped data carrier (2), with a pivotable data carrier plate (4), which features a receptacle for the data carrier (2), said data carrier ( ...


5
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, IPRM Floor 43, January 20, 2011: US20110015192-A1

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


6
Christoph H Westphal, Marc Donath, Peter Elliott, Michael Jirousek, Jill Milne: Sirt1 polymorphic variants and methods of use thereof. May 12, 2011: US20110113498-A1

Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be perfor ...


7
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 8, 2009: US20090012080-A1

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


8
Olivier Boss, Siva Worcester, Andre Iffland, Jesse Smith, Jill Milne, Michael Jirousek: Biomarkers of sirtuin activity and methods of use thereof. Sirtris Pharmaceuticals, Ropes & Gray, August 26, 2010: US20100215632-A1

Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods ...