1
John F Gerster, Kyle J Lindstrom, Gregory J Marszalek, Bryon A Merrill, John W Mickelson, Michael J Rice: Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, August 29, 2000: US06110929 (166 worldwide citation)

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and ...


2
John F Gerster, Kyle J Lindstrom, Stephen L Crooks, Philip D Heppner, Gregory J Marszalek, Peter V Maye, Bryon A Merrill, John W Mickelson, Michael J Rice: Imidazonaphthyridines. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, February 27, 2001: US06194425 (161 worldwide citation)

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compoun ...


3
Patrick L Coleman, Stephen L Crooks, Kyle J Lindstrom, Bryon A Merrill, Michael J Rice: Amide substituted imidazoquinolines. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, September 17, 2002: US06451810 (160 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of condi ...


4
Stephen L Crooks, Kyle J Lindstrom, Bryon A Merrill, Michael J Rice: Sulfonamide and sulfamide substituted imidazoquinolines. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, December 18, 2001: US06331539 (158 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment ...


5
Michael J Rice, Mark A Tomai, Ai Ping Wei: Dye labeled imidazoquinoline compounds. 3M Innovative Properties Company, MarySusan Howard, Ted K Ringsred, Robert W Sprague, April 23, 2002: US06376669 (157 worldwide citation)

Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.


6
Stephen L Crooks, Bryon A Merrill, Michael J Rice: Urea substituted imidazoquinolines. 3M Innovative Properties Company, Dean A Ersfeld, April 1, 2003: US06541485 (149 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in ...


7
Stephen L Crooks, George W Griesgraber, Kyle J Lindstrom, Bryon A Merrill, Michael J Rice: Urea substituted imidazoquinolines. 3M Innovative Properties Company, Dean A Ersfeld, June 3, 2003: US06573273 (149 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in ...


8
Leslie J Charles, Joseph F Dellaria, George W Griesgraber, Philip D Heppner, Karl J Manske, John W Mickelson, Michael J Rice: Heterocyclic ether substituted imidazoquinolines. 3M Innovative Properties Company, Dean A Ersfeld, December 16, 2003: US06664260 (143 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the ...


9
Patrick L Coleman, Stephen L Crooks, George W Griesgraber, Kyle J Lindstrom, Bryon A Merrill, Michael J Rice: Amide substituted imidazoquinolines. 3M Innovative Properties Company, Dean A Ersfeld, June 29, 2004: US06756382 (114 worldwide citation)

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of condi ...


10
John F Gerster, Kyle J Lindstrom, Gregory J Marszalek, Bryon A Merrill, John W Mickelson, Michael J Rice: Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof. 3M Innovative Properties Company, Dean A Ersfeld, August 27, 2002: US06440992 (72 worldwide citation)

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis fa ...