1
Michael J Heller, Eugene Tu: Active programmable electronic devices for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, February 25, 1997: US05605662 (631 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop ...


2
Michael J Heller, Eugene Tu, William F Butler: Molecular biological diagnostic systems including electrodes. Nanogen, Lyon & Lyon, May 27, 1997: US05632957 (506 worldwide citation)

A system for performing molecular biological diagnosis, analysis and multi-step and multiplex reactions utilizes a self-addressable, self-assembling microelectronic system for actively carrying out controlled reactions in microscopic formats. These reactions include most molecular biological procedu ...


3
Ronald G Sosnowski, William F Butler, Eugene Tu, Michael I Nerenberg, Michael J Heller, Carl F Edman: Methods and procedures for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, April 18, 2000: US06051380 (247 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and bi ...


4
Michael J Heller, Edward J Jablonski: Fluorescent stokes shift probes for polynucleotide hybridization. Syngene, Pretty Schroeder Brueggemann & Clark, February 26, 1991: US04996143 (235 worldwide citation)

Fluorescent stokes shift probes for polynucleotide hybridization assays are designed to provide predetermined nucleotide base unit spacings between the donor and acceptor fluorophores. When the probes are hybridized to the target polynucleotide the fluorophores paired for non-radiative energy transf ...


5
Michael J Heller: Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system. Nanogen, Lyon & Lyon, October 15, 1996: US05565322 (174 worldwide citation)

The presence invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, a ...


6
Michael J Heller: Methods for electronic stringency control for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, January 25, 2000: US06017696 (163 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and bi ...


7
Michael J Heller, Eugene Tu: Methods for electronic synthesis of polymers. Nanogen, Lyon & Lyon, July 27, 1999: US05929208 (125 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop ...


8
Michael J Heller: Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system. Nanogen, Lyon & Lyon, December 15, 1998: US05849489 (120 worldwide citation)

The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor--donor transfer distance, a ...


9
Michael J Heller, Eugene Tu, Ronald G Sosnowski, James P O Connell: Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis. Nanogen, Lyon & Lyon, April 11, 2000: US06048690 (114 worldwide citation)

Methods for electronic perturbation of fluorescence, chemilluminescence and other emissive materials provide for molecular biological analysis. In a preferred method for hybridization analysis of a sample, an electronic stringency control device is used to perform the steps of: providing the sample, ...


10
Michael J Heller: Self-organizing molecular photonic structures based on chromophore- and fluorophore-containing polynucleotides and methods of their use. Enterprise Partners II, Lyon & Lyon, July 2, 1996: US05532129 (94 worldwide citation)

The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, an ...



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