1
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University, John P White, August 16, 1983: US04399216 (700 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


2
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University in the City of New York, John P White, January 6, 1987: US04634665 (314 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


3
W Clark Still, Michael H Wigler, Michael H J Ohlmeyer, Lawrence W Dillard, John C Reader: Complex combinatorial chemical libraries encoded with tags. The Trustees of Columbia University in the City of New York, Cold Spring Harbor Laboratory, John P White, October 15, 1996: US05565324 (265 worldwide citation)

Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and syntheti ...


4
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University in the City of New York, John P White, January 12, 1993: US05179017 (265 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


5
Michael H Wigler, Joseph A Sorge: Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. Stratagene, Knobbe Martens Olson & Bear, July 14, 1998: US05780225 (261 worldwide citation)

A method of producing libraries of genes encoding antigen-combining molecules or antibodies; a method of producing antigen-combining molecules which does not require an in vivo procedure; a method of obtaining antigen-combining molecules of selected specificity which does not require an in vivo proc ...


6
Michael H Wigler, John J Colicelli: Cloning by complementation and related processes. Cold Spring Harbor Laboratories, Marshall O Toole Gerstein Murray & Borun, November 2, 1999: US05977305 (192 worldwide citation)

Disclosed are methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the microorganism. Disclosed also are mammali ...


7
Michael H Wigler, John J Colicelli: Cloning by complementation and related processes. Cold Spring Harbor Laboratory, Marshall O Toole Gerstein Murray & Borun, August 8, 2000: US06100025 (184 worldwide citation)

Disclosed are methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the microorganism. Disclosed also are mammali ...


8
W Clark Still, Michael H Wigler, Michael H J Ohlmeyer, Lawrence W Dillard, John C Reader: Complex combinatorial chemical libraries encoded with tags. Trustees of Columbia University in the City of New York, Cold Spring Harbor Laboratory, Pennie & Edmonds, February 24, 1998: US05721099 (93 worldwide citation)

Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and syntheti ...


9
W Clark Still, Michael H Wigler, Michael H J Ohlmeyer, Lawrence W Dillard, John C Reader: Methods of determining the structure of a compound encoded by identifiers having tags. Trustees of the Columbia University in the City of New York, Cold Spring Harbor Laboratory, Pennie & Edmonds, August 4, 1998: US05789172 (49 worldwide citation)

Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and syntheti ...


10
W Clark Still, Michael H Wigler, Michael H J Ohlmeyer, Lawrence W Dillard, John C Reader: Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags. The Trustees of Columbia University, Cold Spring Harbor Laboratory, John P Cooper & Dunham White, December 14, 1999: US06001579 (46 worldwide citation)

Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and syntheti ...