1
Irving K Arenberg, Michael H Arenberg: Inner ear fluid transfer and diagnostic system. IntraEar, Jay K Klaas Law O Meara & Malkin P C Malkin, April 4, 2000: US06045528 (100 worldwide citation)

An apparatus for transferring fluids into and out of the inner ear through the round window membrane. The apparatus includes a cover member sized for placement over the round window niche. Fluid delivery and fluid extraction conduits are provided which are operatively connected to the cover member s ...


2
Irving K Arenberg, Michael H Arenberg: Fluid transfer and diagnostic system for treating the inner ear. Durect Corporation, Carol L Francis, Paula A Borden, Bozicevic Field & Francis, August 27, 2002: US06440102 (99 worldwide citation)

An apparatus for delivering fluid materials into and out of the inner ear via the round window membrane. A fluid transfer conduit is provided which includes one or more passageways therethrough which may have a semipermeable membrane associated therewith to control fluid flow. Attached to the condui ...


3
Michael H Arenberg, Edward M Gillis, Charles R Rampersaud: Aural catheter system including anchor balloon and balloon inflation device. Durect, Adam W Bell, November 18, 2003: US06648873 (73 worldwide citation)

Methods and apparatus used for securing the end of a drug-delivery catheter at the round window niche of the inner ear; specifically an apparatus employing a miniature threaded screw pump to inflate a balloon allowing a catheter to be secured within the round window niche of the inner ear.


4
Irving K Arenberg, Michael H Arenberg, Christine Lemke, John A Berglund: Controlled release system for delivering therapeutic agents into the inner ear. Durect Corporation, Adam Bell, February 3, 2004: US06685697 (42 worldwide citation)

The present invention provides methods and devices for controlled delivery of a therapeutic agent to an internal cavity of the ear, particularly to the inner ear. In general, the invention uses a drug delivery unit for inner ear treatment which employs a portion of carrier media material containing ...


5
Irving K Arenberg, Michael H Arenberg, Christine Lemke, John A Berglund: Controlled release system for delivering therapeutic agents into the inner ear. Durect Corporation, June 12, 2012: US08197461 (11 worldwide citation)

A specialized drug delivery unit for inner ear treatment which employs a portion of carrier media material containing one or more therapeutic agents therein. The carrier media material is designed to release the therapeutic agents in a controlled manner over time. The drug delivery unit is sized for ...


6
Jan J Scicinski, William W van Osdol, Huey Ching Su, Michael H Arenberg, Jaymin Shah: Oral pharmaceutical dosage forms. Durect Corporation, Michael B Rubin, Bozicevic Field & Francis, April 11, 2017: US09616055

Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.


7
Michael H Arenberg, Charles Rampersaud, Edward M Gillis, Su Il Yum, Felix Theeuwes: Device and method for delivering microdoses of agent to the ear. Durect Corporation, September 2, 2004: US20040172005-A1

The present invention provides devices and methods for delivery of very low dosages to the inner ear. The device is a self-contained unit that reproducibly and consistently delivers a dose of therapeutic agent that is effective, yet below the ototoxic threshold for that agent. The invention further ...


8
Michael H Arenberg, Edward M Gillis, Charles R Rampersaud: Aural catheter system including anchor balloon and balloon inflation device. Adam Warwick Bell DPhil, March 27, 2003: US20030060799-A1

Methods and apparatus used for securing the end of a drug-delivery catheter at the round window niche of the inner ear; specifically an apparatus employing a miniature threaded screw pump to inflate a balloon allowing a catheter to be secured within the round window niche of the inner ear.


9
Jan J Scicinski, William W van Osdol, Huey Ching Su, Michael H Arenberg, Jaymin Shah: Oral pharmaceutical dosage forms. Durect Corporation, Thomas P Mccracken, October 14, 2010: US20100260844-A1

Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.