1
Michael D Pierschbacher, Erkki I Ruoslahti: Polypeptide. La Jolla Cancer Research Foundation, Fulwider Patton Rieber Lee & Utecht, May 20, 1986: US04589881 (176 worldwide citation)

A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala- Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr -Tyr-Arg-Ile-Thr-Tyr-Gl ...


2
Michael D Pierschbacher: Vitronectin specific cell receptor derived from mammalian mesenchymal tissue. La Jolla Cancer Research Foundation, Pretty Schroeder Brueggemann & Clark, December 6, 1988: US04789734 (152 worldwide citation)

A method of isolating cell surface receptors utilizing a short peptide sequence bound to an affinity column. Cell surface receptors which bind selectively to the short peptide and which are specific to various adhesion proteins may be isolated therewith from various cell preparations. These receptor ...


3
Erkki I Ruoslahti, Michael D Pierschbacher: Polypeptide. La Jolla Cancer Research Foundation, Hubbard and Stetina, May 21, 1985: US04517686 (111 worldwide citation)

A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala- Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr -Tyr-Arg-Ile-Thr-Tyr-Gl ...


4
Erkki I Ruoslahti, Michael D Pierschbacher: Polypeptide. La Jolla Cancer Research Foundation, Irell & Manella, April 28, 1987: US04661111 (109 worldwide citation)

A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala- Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr -Tyr-Arg-Ile-Thr-Tyr-Gl ...


5
Ralph Heiko Mattern, Michael D Pierschbacher, Fred Cahn, Juerg Friederich Tschopp, Timothy Irvin Malaney: Collagen/glycosaminoglycan matrix stable to sterilizing by electron beam radiation. Integra LifeSciences Corporation, Licata & Tyrrell P C, November 29, 2005: US06969523 (46 worldwide citation)

Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal sterilization. Also provided are methods for producing these compositions and terminally sterilized matrices or ...


6
Michael D Pierschbacher, Soan Cheng, William S Craig, Juerg F Tschopp: Method and composition for treating thrombosis. La Jolla Cancer Research Foundation, Campbell & Flores, September 30, 1997: US05672585 (43 worldwide citation)

The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic amino acids adjacent to the carboxy terminus of the RGD sequence. Peptides of this natur ...


7
Michael D Pierschbacher, Cyril J Honsik, Lisa B Dreisbach: Hydrophobic attachment site for adhesion peptides. La Jolla Cancer Research Foundation, Pretty Schroeder Brueggemann & Clark, June 9, 1992: US05120829 (35 worldwide citation)

The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, va ...


8
Erkki I Ruoslahti, Edward G Hayman, Michael D Pierschbacher: Peptides in cell detachment and aggregation. La Jolla Cancer Research Foundation, Pretty Schroeder Brueggemann & Clark, January 29, 1991: US04988621 (31 worldwide citation)

A method of using synthetic cell attachment-promoting peptides from fibronectin to detach cultured cells from the substratum is described.


9
Eric I Rudslahti, Edward G Hayman, Michael D Pierschbacher: Use of peptides in control of cell attachment and detachment. La Jolla Cancer Research Foundation, Pretty Schroeder Brueggemann & Clark, November 7, 1989: US04879237 (27 worldwide citation)

A method of using synthetic cell attachment-promoting peptides from fibronectin to detach cultured cells from the substratum is described.


10
Erkki I Ruoslahti, Michael D Pierschbacher, Jose Cardenas, William Craig, Daniel G Mullen: Decorin fragments inhibiting cell regulatory factors. La Jolla Cancer Research Foundation, Campbell & Flores, January 6, 1998: US05705609 (22 worldwide citation)

The present invention provides a method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucin ...