1
Kevin Rodzinak
Donna J Armstrong, Essa H Hu, Michael J Kelly III, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Michael A Rossi, Philip E Sanderson, Jiabing Wang: Inhibitors of akt activtiy. Merck, September 2, 2010: US20100222321-A1

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


2
Michael A Rossi, Joel M Cormier, Donald S Smith, Matthew M Gerwolls: Apparatus making thermoformed component with integral coined structure. SafetyNet Energy Management, Price Heneveld Cooper DeWitt & Litton, December 28, 2010: US07857610 (7 worldwide citation)

A thermoforming process capable of coining and flowing material is provided, such as for making a thermoformed energy absorber for self-attachment to a vehicle bumper beam. The energy absorber includes a thermoplastic sheet with first thickness shaped by a thermoforming process to include a base and ...


3
Matthew M Gerwolls, Michael A Rossi, Dane Winbigler, Donald S Smith, Joel M Cormier, Richard F Audi: Energy absorber with anti-squeak anti-rattle feature. Oakwood Energy Management, Brooks Kushman P C, June 18, 2013: US08465087 (7 worldwide citation)

An energy absorber includes a base sheet and a plurality of crush lobes extending from the base sheet. Each crush lobe includes a side wall oriented to crush and collapse to absorb energy when impacted in a first direction and includes an end wall. At least one of the base sheet and the end wall of ...


4
Michael A Rossi, Joel M Cormier, Donald S Smith, Matthew M Gerwolls: Thermoformed product with coined region. SafetyNet Energy Management, Price Heneveld, August 9, 2011: US07993725 (2 worldwide citation)

A thermoformed product formed during a thermoforming process includes a thermoformed sheet of polymeric material having front and rear surfaces defining a thickness, and having a first section thermoformed to include a non-planar three-dimensional useful structure and at least one second section. Ea ...


5
Matthew M Gerwolls, Michael A Rossi, Dane Winbigler, Donald S Smith, Joel M Cormier, Richard F Audi: Recoverable energy absorber. Oakwood Energy Management, Brooks Kushman P C, April 7, 2015: US08998298 (1 worldwide citation)

An energy absorber includes a base sheet and a plurality of recovering crush lobes extending from the base sheet. The crush lobes protect an adjacent object by cushioning the blow following repeated impacts in both vehicular and non-vehicular (e.g. helmets) environments. Each crush lobe includes a s ...


6
Hidetomo Furuyama, Yasuhiro Goto, Nobuhiko Kawanishi, Mark E Layton, Takashi Mita, Yoshio Ogino, Yu Onozaki, Michael A Rossi, Toshihiro Sakamoto, Philip E Sanderson, Jiabing Wang: Inhibitors of AKT activity. Merck Sharp & Dohme, MSD, Yong Zhao, David A Muthard, Matthew A Leff, September 17, 2013: US08536193

The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibi ...


7
Joel M Cormier, Michael A Rossi, Donald S Smith, Richard F Audi, Aton Mahdi: Energy absorber with anti-BSR accessory. Oakwood Energy Management, Brooks Kushman P C, May 9, 2017: US09644699

An energy absorber includes a base sheet and a plurality of energy absorbing units with end walls and associated leaf spring or helicoid accessories extending from the base sheet. The accessories reduce buzzes, squeaks and rattles associated with an environment of use. In one embodiment, the leaf sp ...


8
Hannah D Fiji, Michael J Kelly III, Jeffrey C Kern, Mark E Layton, Joseph E Pero, Alexander J Reif, Michael A Rossi: Imidazopyridin-2-one derivatives. Merck Sharp & Dohme, Keith D MacMillan, John C Todaro, April 19, 2016: US09315518

The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and ...


9
Mark E Layton, Joseph E Pero, Hannah Fiji, Michael J Kelly III, Pablo de Leon, Michael A Rossi, Kevin F Gilbert, Anthony J Roecker, Zhijian Zhao, Swati I P Mercer, Scott Wolkenberg, James Mulhearn, Lianyun Zhao, Dansu Li: Benzoxazolinone compounds with selective activity in voltage-gated sodium channels. Merck Sharp & Dohme, H Eric Fischer, John C Todaro, March 1, 2016: US09273040

Disclosed are compounds of Formula (A) or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (A) or their ...


10
Joseph E Pero, Hannah D G F Lehman, Mark E Layton, Michael A Rossi, Michael J Kelly III: N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels. Merck Sharp & Dohme, John C Todaro, H Eric Fischer, July 12, 2016: US09388179

Disclosed are compounds of Formula AA and Formula AB: wherein “Heteroaryl-1”, RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the c ...



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